Clinical study of Beclomethasone Dipropionate Nasal Spray combined with Biyuan Mixture in the treatment of allergic rhinitis with wind-cold-dampness obstruction pattern
Objective lo investigate the clinical effect of Beclomethasone Dipropionate Nasal Spray combined with Biyuan Mixture in the treat-ment of allergic rhinitis with wind-cold-dampness obstruction pattern.Methods A total of 126 allergic rhinitis patients with wind-cold-dampness obstruction pattern admitted to the Department of Otolaryngology,Haian Traditional Chinese Medicine Hospital,Jiangsu Province from June 2021 to May 2023 were selected as the study objects.According to random number table method,they were divided into western medicine group,Chinese medicine group,and combined group,each with 42 cases.The western medicine group was treated with Beclomethasone Dipropionate Nasal Spray,the Chinese medicine group was treated with Biyuan Mixture,and the combined group was treated with two drugs.After four weeks of treatment,the clinical efficacy and the nasal mucosal symptoms(nasal symptoms visual analogue scale[VAS]score,total nasal symptoms score[TNSS],total nasal and non-nasal symptom score[TINNSS]),markers of nasal mucosal inflammation(mucoprotein-5AC[MUC5AC],interleukin-6[IL-6],interfer-on-γ[IFN-γ]),and nasal function(nasal airway resistance[NAR],nasal minimum cross-sectional area[NMCA],and 0-5 cm nasal volume[0-5 cmNCV])of the three groups before and after treatment were compared.Results The curative effect of combined group was better than that of west-ern medicine group and Chinese medicine group(P＜0.05).After treatment,the nasal symptoms VAS,TNSS,and TNNSS scores of the three groups were lower than those before treatment,and those of combined group were lower than those of western medicine group and Chinese medicine group(P＜0.05).After treatment,the levels of MUC5AC and IL-6 in the three groups were lower than those before treatment,and the levels of IFN-γwere higher than that before treatment,and the levels of MUC5AC and IL-6 in the combined group were lower than those in the western medicine group and the Chinese medicine group,and the level of IFN-γ was higher than those in the western medicine group and the Chinese medicine group(P＜0.05).After treatment,NAR in the three groups was lower than that before treatment,NMCA,0-5 cmNCV were higher than those before treatment,and NAR in the combined group was lower than that in western medicine group and Chinese medicine group,and NMCA,0-5 cmNCV were higher than those in the western medicine group and Chinese medicine group(P＜0.05).Conclusion The combination of Beclomethasone Dipropionate Nasal Spray and Biyuan Mixture in the treatment of allergic rhinitis with wind-cold-dampness obstruction pattern shows a good effect,can effectively reduce the nasal mucosal inflammation,improve the quality of life of patients,and has a greater value in clinical promotion.
万方数据
维普
