Diagnostic value comparison of six commonly used serological diagnostic models for liver fibrosis in adult hepatitis B e-antigen positive patients
Objective To compare diagnostic value of six commonly used serological diagnostic models for liver fibrosis in adult hepatitis B e-anti-gen positive patients.Methods Two hundred and sixty-five patients diagnosed with chronic hepatitis B and underwent liver pathological tissue biopsy from January 2018 to June 2023 at Zibo Central Hospital of Shandong Province and Sixth Medical Center of Chinese PLA General Hospital were selected as research subjects.Relevant indicators of six commonly used clinical serological diagnostic models including gamma-glutamyl-transpeptidase to platelet ratio(GPR),fibrosis 4 factor index(FIB-4),aspartate aminotransferase to platelet ratio index(APRI),aspartate to alanine aminotransferase ratio(AAR),fibrosis cirrhosis index(FCI),and S-index were collected.Liver tissue biopsy results as"gold standard"the curve of receiver operating characteristic was used to evaluate diagnostic performance of six models.Results There were significant differences in age,platelet count,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,gamma-glutamyl transpeptidase,albumin,APRI,FIB-4,GPR,S-index,and FCI among stages F1-F4(P＜0.05).When distinguishing F1-F4,areas under the curves of GPR,APRI,FIB-4,FCI,and S-index models were all greater than 0.70,and 95％CI of area under the curve of AAR model included 0.50.When distinguishing between F 1 and F2-F4,F1-F2 and F3-F4,F1-F3 and F4,area under the curves of GPR,APRI,FIB-4,FCI and S-index models were greater than those of AAR model(P＜0.05).Conclusion FIB-4,GPR,S-index,and FCI can effectively distinguish severity of liver fibrosis in chronic hepatitis B patients with positive hepatitis B e-antigen.Discriminative power of APRI gradually decreases in order of F1 to F4,and AAR is basically unable to judge severity of liver fibrosis.
Diagnostic modelsHepatitis B e-antigen positiveLiver fibrosisChronic hepatitis B
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NSTL
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