Study on the medication rules in the treatment of epilepsy by national patent of traditional Chinese medicine compound prescription
Objective To analyze and summarize the medication rules in the treatment of epilepsy by national patent of traditional Chinese medicine compound prescription through data mining technology.Methods Through the official website of the China Patent Publication An-nouncement of the State Intellectual Property Office,the patent data of traditional Chinese medicine compound prescription for the treatment of epilepsy from the inception to September 2023 were retrieved.The Ancient and Modern Medical Records Cloud Platform(V2.3.5)was used for sta-tistical analysis of the use frequency,four natures,five flavours,and channel tropism of the compound prescription drugs,and correlation analysis,cluster analysis,and complex network analysis were carried out.Results A total of 297 traditional Chinese medicine compound prescription meet-ing the standard were included,involving 609 kinds of traditional Chinese medicine.The high frequency drugs were Gastrodiae Rhizoma,Acori Tatarinowii Rhizoma,Scorpio,Bombyx Batryticatus,Uncariae Ramulus Cum Uncis,and Arisaema Cum Bile.In terms of nature,flavour,and channel tropism,the drug natures were mainly flat,warm,cold,and slightly cold.The drug flavours were mainly sweet,pungent,and bitter.The channel tropisms were mainly liver,heart,lung,and spleen channels.In terms of drug efficacy,the use of traditional Chinese medicine such as clearing heat and removing toxicity,arresting epilepsy by calming endogenous wind,calming the panic by calming endogenous wind,and calming liver-yang is more frequent.Correlation analysis indicated that the high frequency drug combinations were"Scorpio-Bombyx Batryticatus","Bombyx Batryticatus-Gastrodiae Rhizoma",and so on.Drug clustering can cluster the top 20 kinds of Chinese medicine used frequently into five categories.By complex network analysis,the core prescriptions for the treatment of epilepsy were Scorpio,Bombyx Batryticatus,Gastrodiae Rhi-zoma,Acori Tatarinowii Rhizoma,Uncariae Ramulus Cum Uncis,Arisaema Cum Bile,Scolopendra,Polygalae Radix,Glycyrrhizae Radix Et Rhizoma,amber,and Cinnabaris.Conclusion Based on the pathogenesis of"wind","phlegm",and"heat"of epilepsy,the patent of traditional Chinese medicine compound prescription for the treatment of epilepsy is based on the core treatment of clearing heat and calming endogenous wind,calming panic and stopping epilepsy,eliminating phlegm,and clearing collagalors in the remission period,and warming cultivation and toning.
EpilepsyPatent of traditional Chinese medicine compound prescriptionData miningMedication regularity
NETL
NSTL
万方数据
