Relationship between MutL protein homologue 1/MutS protein homologue 2 expression loss and clinicopathological features and prognosis of diffuse gastric cancer
Objective To investigate the relationship between the MutL protein homologue l(MLH1)/MutS protein homologue 2(MSH2)expres-sion loss and the clinicopathological features and prognosis of diffuse invasive gastric cancer.Methods Clinical data of 157 patients with diffuse in-vasive gastric cancer admitted to the Second Affiliated Hospital of Wannan Medical College from March 2020 to July 2022 were retrospectively ana-lyzed,and the relationship between MLH1/MSH2 expression loss and clinicopathological features of diffuse invasive gastric cancer was analyzed.The survival of patients was recorded during 1-year follow-up,and the factors influencing prognosis of patients with diffuse invasive gastric cancer were analyzed.Results Among 157 patients,MLH1/MSH2 expression loss was 16 cases(10.19％).The loss rate of MLH1/MSH2 expression in pa-tients with low differentiation,stage Ⅲ,and lymph node metastasis was higher than patients with medium and high differentiation,stage Ⅰ to Ⅱ,and no lymph node metastasis and the difference was statistically significant(P＜0.05).After one-year follow-up,the survival curve of patients without MLH1/MSH2 expression loss was better than patients with MLH1/MSH2 expression loss and the difference was statistically significant(P＜0.05).TNM stage,postoperative complications,and MLH1/MSH2 expression loss were risk factors for prognosis in patients with diffuse invasive gastric cancer(P＜0.05).Conclusion The MLH1/MSH2 expression loss is closely related to tumor differentiation,TNM stage,lymph node metasta-sis and prognosis of patients with diffuse invasive gastric cancer,and the prognosis of patients with MLH1/MSH2 expression loss is worse.
MutL protein homologue 1/MutS protein homologue 2Diffuse invasive gastric cancerClinicopathological featuresPrognosis
NETL
NSTL
万方数据
