Clinical effect of Sangxing Zhike Prescription in treating cough variant asthma with dryness pathogen impairing lung syndrome in dry and low altitude area
Objective To investigate the clinical effect of Sangxing Zhike Prescription in treating cough variant asthma(CVA)with dryness pathogen impairing lung syndrome in dry and low altitude area.Methods A total of 240 patients with CVA admitted to Department of Respiratory,Gaochang District People's Hospital in Turpan City,Xinjiang Uygur Autonomous Region from January 2022 to September 2023 were selected and they were divided into control group and observation group according to random number table method,with 120 cases in each group.The two groups were treated continuously for two weeks,and the clinical efficacy,Leicester cough quality of life score(LCQ),visual analogue scale(VAS),pulmonary function,neutrophil,and eosinophilic changes were compared before and after treatment.Results The clinical effect of the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).Before treatment,there were no significant differences in LCQ and VAS scores between the two groups(P＞0.05).After treatment,LCQ score in both groups was higher than before treatment,and that in the observation group was higher than that in the control group,and the VAS score in both groups was lower than before treatment,and that in the observation group was lower than that in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference in lung function between the two groups(P＞0.05).After treatment,the forced vital capacity(FVC)in observation group was higher than before treatment,and that in observation group was higher than that in control group,and the differences were statistically significant(P＜0.05);the forced expiratory volume in first second(FEV1),and FEV1/FVC lung function in both groups were higher than before treatment,and those in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in neutrophil count,lymphocyte count,neutrophil/lymphocyte ratio,and eosinophilic count between the two groups(P＞0.05).After treatment,neutrophil count and neutrophil/lymphocyte ratio in two groups were lower than before treatment,and the differences were statistically significant(P＜0.05).After treatment,there was no significant difference in neutrophil count and neutrophil/lymphocyte ratio between the two groups(P＞0.05).Before treatment,there was no significant difference in lymphocyte count and eosinophil count between the two groups(P＞0.05).After treatment,there was no significant difference in lymphocyte count and eosinophil count between the two groups compared with before treatment(P＞0.05).After treatment,the lymphocyte count and eosinophil count in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Sangxing Zhike Prescription can reduce the level of serum inflammation and improve the curative effect of CVA patients.
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