Effect of Wendan Decoction on the levels of serum brain derived neu-rotrophic factor and 5-hydroxytryptamine in patients with depression
Objective To investigate the effects of Wendan Decoction on the levels of serum brain derived neurotrophic factor(BDNF)and 5-hy-droxytryptamine(5-HT)in patients with depression.Methods A total of 100 patients with depression in Suzhou Guangji Hospital,Jiangsu Province from January 2022 to April 2023 were selected and they were divided into observation group and control group according to random number table method,with 50 cases in each group.The control group was given conventional antidepressants,and the observation group was combined with Wen-dan Decoction on the basis of control group.Both groups were treated for eight weeks.The clinical efficacy of the two groups was compared,and the medical syndrome score before and after treatment was compared.In addition,the serum BDNF and 5-HT levels of the two groups were measured before and after treatment,and the occurrence of adverse reactions of the two groups were compared.Results The clinical effect of the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).Before treatment,there was no significant difference in traditional Chinese medicine syndrome scores between the two groups(P＞0.05).After treatment,the scores of traditional Chinese medicine symptoms in both groups were decreased before treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in serum BDNF and 5-HT levels between the two groups(P＞0.05).After treatment,the serum levels of BDNF and 5-HT in two groups were higher than before treatment,and the observation group was higher than the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Wendan Decoction can not only effectively improve the clinical symptoms of patients with depression,but also improve the levels of serum BDNF and 5-HT,and it is safe.
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