Clinical effect of Zhishi Xiaopi Pills Huacai Prescription combined with acupoint application in the treatment of opioid-induced constipation of spleen deficiency and qi stagnation type
Objective To investigate the clinical effect of Zhishi Xiaopi Pills Huacai Prescription combined with acupoint application in the treat-ment of opioid-induced constipation(OIC)of spleen deficiency and qi stagnation type.Methods Seventy patients with spleen deficiency and qi stagnation OIC hospitalized in Shijiazhuang Hospital of Traditional Chinese Medicine from February 2022 to February 2023 were selected and they were divided into treatment group and control group according to random number table method,with 35 cases in each group.The treatment group was treated with Zhishi Xiaopi Pills Huacai Prescription combined with acupoint application,and the control group was treated with Lactulose.Continuous treatment for two weeks.The scores of major constipation symptoms,the Chinese version of patient assessment of constipation quality of life(PAC-QOL)scores and the levels of serum gastrointestinal hormones(substance P[SP],motilin[MTL],vasoactive intestinal peptide[VIP])be-fore and after treatment were compared between the two groups,and the clinical efficacy was evaluated.Results Before treatment,there were no significant differences in the frequency of defecation,defecation effort,defecation time,abdominal distension,fall,fullness and feeling of distension,and fecal traits scores between the two groups(P＞0.05).After treatment,the scores of defecation frequency,defecation effort,defecation time,ab-dominal distension,fall,fullness and feeling of distension,and fecal traits of the two groups were lower than before treatment,and those in the treat-ment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no statistical significances in the scores of physiological,social psychological,worry and anxiety and satisfaction in PAC-QOL scale between the two groups(P＞0.05).After treatment,the scores of physiological,social psychological,worry and anxiety and satisfaction in PAC-QOL scale of two groups were lower than before treatment,and those in the treatment group were lower than those in the control group,and the differences were sta-tistically significant(P＜0.05).Before treatment,there were no significant differences in VIP,MTL,and SP levels between the two groups(P＞0.05).After treatment,the VIP level of the two groups was lower than before treatment,and the MTL and SP levels were higher than before treat-ment,and the VIP level of the treatment group was lower than the control group,and the MTL and SP levels were higher than the control group,and the differences were statistically significant(P＜0.05).The clinical effect of the treatment group was better than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Zhishi Xiaopi Pills Huacai Prescription combined with acupoint application can reduce the severity of OIC and improve the quality of life in patients with cancer pain caused by spleen deficiency and qi stagnation,which has good clinical efficacy,and is considered to have a correlation with its ability to regu-late the level of gastrointestinal hormones.
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