Relationship between serum complement C1q/tumor necrosis factor-related protein 3 and vimentin levels and prognosis in chronic heart failure patients with dilated cardiomyopathy
Objective To investigate the relationship between serum complement C1q/tumor necrosis factor-related protein 3(CTRP3)and vimentin(VTN)levels and prognosis in chronic heart failure patients with dilated cardiomyopathy.Methods A total of 179 patients with dilated cardiomyopathy chronic heart failure admitted to Xingtai Central Hospital,Hebei Province from January 2021 to August 2022 were selected and they were divided into poor prognosis group(63 cases)and good prognosis group(116 cases)according to one-year prognosis.Serum CTRP3 and VTN levels were detected by enzyme linked immunosorbent assay.Univariate and multivariate logistic regression analysis were conducted to analyze the prognostic factors of dilated cardiomyopathy chronic heart failure,and the predictive value of serum CTRP3 and VTN levels on poor prognosis of patients with dilated cardiomyopathy chronic heart failure was analyzed by receiver operator characteristic curve.Results After one year follow-up,the incidence of poor prognosis in 179 patients with dilated cardiomyopathy chronic heart failure was 35.20％(63/179).There were significant dif-ferences in age,duration of chronic heart failure,cardiac function grade,left ventricular ejection fraction(LVEF),CTRP3,and VTN between the two groups(P＜0.05).There were no significant differences in gender,smoking history,drinking history,combined diseases,systolic blood pressure,di-astolic blood pressure,therapeutic drugs,and instrument-assisted treatment between the two groups(P＞0.05).Age increased(OR[95％CI]:1.090[1.007-1.179]),cardiac function grade increased(OR[95％CI]:3.868[1.405-10.652]),VTN increased(OR[95％CI]:1.101[1.039-1.167]),LVEF increased(OR[95％CI]:0.680[0.543-0.850])and CTRP3 increased(OR[95％CI]:0.946[0.916-0.978])were influential factors for poor prognosis in patients with dilated cardiomyopathy chronic heart failure(P＜0.05).The area under the curve of CTRP3 combined with VTN in pre-dicting poor prognosis of patients with chronic heart failure in dilated cardiomyopathy(0.878)was greater than 0.782 and 0.787 predicted by CTRP3 and VTN alone(Z=3.779,3.546,P＜0.05).Conclusion The de-crease of serum CTRP3 level and the increase of VTN level are closely re-lated to poor prognosis in patients with dilated cardiomyopathy chronic heart failure.The combined value of CTRP3 and VTN is higher in predicting poor prognosis of chronic heart failure of dilated cardiomyopathy.
Dilated cardiomyopathyChronic heart failureComplement C1q/tumor necrosis factor-related protein 3VitronectinPrognosis
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