Effects of Esketamine combined with Flurbiprofen Axetil on postoperative analgesia effect and depressive symptoms in elderly obese pregnant wom-en after cesarean section
Objective To explore the effects of Esketamine combined with Flurbiprofen Axetil on postoperative analgesia effect and depressive symptoms in elderly obese pregnant women after cesarean section.Methods A total of 100 cases of elderly obese pregnant women who underwent cesarean section in Ningguo City People's Hospital of Anhui Province from January 2022 to October 2023 were selected as the study subjects,and they were divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The control group was given Esketamine for analgsia,and the observation group was given Esketamine combined with Flurbiprofen Axetil for analgsia.The motor block effect of the two groups were compared;the heart rate(HR),diastolic blood pressure(DBP),and mean arterial pressure(MAP)of the two groups before anaesthesia(T0),at the moment of anaesthesia(T1),at the end of operation(T2),and 1 h after the operation(T3)were compared;resting and dynamic visual analogue scale(VAS)scores at 4 h(T4),6 h(T5),12 h(T6),24 h(T7),and 36 h(T8)after operation were compared;Edin-burgh postpartum depression scale(EPDS)score and the incidence of postpartum depression(PPD)were compared between two groups one,three,and six weeks after operation were compared;and the occurrence of adverse reactions in the two groups was recorded.Results There was no signifi-cant difference in the motor block effect between the two groups(P＜0.05).Overall analysis found that:There were significant differences in HR,DBP,and MAP time,inter-group comparison,and interaction between the two groups(P＜0.05).Comparison within groups:at T2-T3,HR,DBP,and MAP of the control group were lower than those at T0,and the differences were statistically significant(P＜0.05).Inter-group comparison:at T2-T3,HR,DBP,and MAP in the observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).Overall analysis found that:there were significant differences in resting and dynamic VAS scores time,inter-group comparison,and interac-tion between the two groups(P＜0.05).Comparison within groups:at T5-T8,the resting and dynamic VAS scores of the two groups were higher than those at T4,and the differences were statistically significant(P＜0.05);in-ter-group comparison:at T4-T8,the resting and dynamic VAS scores of the observation group were lower than those of the control group,and the dif-ferences were statistically significant(P＜0.05).Overall analysis found that:there were significant differences in EPDS scores inter-group compari-son between the two groups(P＜0.05).Comparison within groups:at one,three,and six weeks after operation,there were no significant differences in EPDS scores between the two groups at each time point(P＞0.05).Comparison between groups:at one,three,and six weeks after operation,the EPDS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).At one,three,and six weeks after operation,the incidence of PPD in observation group were lower than those in control group,and the differences were sta-tistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Esketamine with Flurbiprofen Axetil has a good analgesic effect on elderly obese pregnant women after cesarean section,and can sig-nificantly improve the symptoms of depression.
NETL
NSTL
万方数据
