Evaluation value of calcification characteristics of magnetic resonance imaging combined with mammography on pathologic complete response of breast cancer after neoadjuvant chemotherapy
Objective To explore the evaluation value of calcification characteristics of magnetic resonance imaging(MRI)combined with mam-mography on pathologic complete response(PCR)of breast cancer after neoadjuvant chemotherapy(NAC).Methods Clinical data of 120 patients with calcification breast cancer received NAC in Fuyang Cancer Hospital of Anhui Province from January 2020 to May 2023 were retrospectively analyzed.According to postoperative pathological results,patients were divided into PCR group(36 cases)and non-PCR group(84 cases).Influ-encing factors of PCR were analyzed.Evaluation value of MRI combined with mammograph for PCR was analyzed by using receiver operator char-acteristic(ROC)curve.Results There were statistically significant differences in clinical stage,Ki-67 proliferation index,calcification morphology,calcification distribution,apparent diffusion coefficient(ADC)and capacity transfer constant(Ktrans)between two groups,and the differences were statistically significant(P＜0.05).Clinical stage(OR=3.010,95％CI:1.435-6.314),Ki-67 proliferation index(OR=4.414,95％CI:1.934-10.073),calcification morphology(OR=2.879,95％CI:1.726-4.860),and ADC(OR=0.217,95％CI:0.120-0.974)were influencing factors for PCR of breast cancer after NAC(P＜0.05).ROC curve showed that area under the curve of PCR predicted by combination of calcification mor-phology and ADC was greater than that predicted by calcification morphology and ADC alone.Conclusion MRI combined with mammography has high evaluation value in PCR of patients with calcification breast cancer after NAC.
Magnetic resonance imagingMammographyBreast cancerCalcificationPathologic complete response
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