The predictive value of combined measurement of S100 β,NSE,and ultra-sound in assessing optic nerve sheath width for the clinical prognosis of patients with moderate-to-severe traumatic brain injury
Objective To explore the predictive value of combined measurement of S100 calcium-binding protein β(S100 β),neuron specific enolase(NSE),and ultrasound in assessing optic nerve sheath width for the clinical prognosis of patients with moderate-to-severe traumatic brain injury.Methods A total of 148 patients with moderate-to-severe traumatic brain injury admitted to Suqian Hospital Affiliated to Xuzhou Medi-cal University from October 2020 to December 2022 were included.Based on the Glasgow outcome scale(GOS)at six months after treatment,patients were divided into a good prognosis group(4-5 scores)and a poor prognosis group(1-3 scores).The serum levels of S100 β,NSE,and optic nerve sheath width at admission were measured.The influencing factors of prognosis in patients with moderate-to-severe traumatic brain injury were analyzed.The predictive value of S100 β,NSE combined with ultrasound in assessing optic nerve sheath width for the clinical prog-nosis of patients with moderate-to-severe traumatic brain injury was evaluated.Results Of the 148 moderate-to-severe traumatic brain injury patients,36 had poor prognosis,accounting for 24.32％.The proportion of severe traumatic brain injury,hematoma volume≥40 ml,acute physi-ology and chronic health evaluation Ⅱ(APACHE Ⅱ)score,S100 β level,NSE level,and optic nerve sheath width in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).Severity(OR=4.509,95％CI:1.664-12.214),hematoma volume(OR=3.655,95％CI:1.349-9.901),APACHE Ⅱ score(OR=3.873,95％CI:1.429-10.491),S100β(OR=4.586,95％CI:1.693-12.423),NSE(OR=4.080,95％CI:1.506-11.052),and optic nerve sheath width(OR=4.540,95％CI:1.676-12.299)were risk factors for poor prognosis in moderate-to-severe traumatic brain injury patients(P＜0.05).The area under the curve for single and combined prediction of prognosis in patients with moder-ate-to-severe traumatic brain injury using S100 β,NSE,and nerve sheath width were 0.726,0.702,0.724,and 0.812,respectively.Conclu-sion The combined measurement of S100 β,NSE,and ultrasound in assessing optic nerve sheath width shows good efficacy in predicting the prognosis of patients with moderate-to-severe traumatic brain injury.
Moderate-to-severe traumatic brain injuryS100 calci-um-binding protein βNeuro specific enolaseOptic nerve sheath widthPrognosis
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