首页|hsa_circ_0090231与hsa_circ_0004543在急性脑梗死患者颈动脉斑块中的临床意义

hsa_circ_0090231与hsa_circ_0004543在急性脑梗死患者颈动脉斑块中的临床意义

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目的 探讨hsa_circ_0090231与hsa_circ_0004543在急性脑梗死(ACI)患者颈动脉斑块中的临床意义.方法 选取2022年1月至12月于浙江省嘉兴市第一医院收治的60例ACI患者作为试验组,根据预后情况分为预后良好组(39例)和预后不良组(21例);选择同期于浙江省嘉兴市第一医院体检中心体检的50例健康体检者作为对照组.采用实时定量聚合酶链反应测定hsa_circ_0090231和hsa_circ_0004543表达;采用Pearson分析hsa_circ_0090231、hsa_circ_0004543与低密度脂蛋白胆固醇(LDL-C)的相关性;采用受试者操作特征(ROC)曲线分析hsa_circ_0090231、hsa_circ_0004543对ACI患者不良预后的诊断效能.结果 试验组hsa_circ_0090231、hsa_circ_0004543及LDL-C水平均高于对照组,差异有统计学意义(P<0.05).预后不良组hsa_circ_0090231、hsa_circ_0004543及LDL-C水平均高于预后良好组,差异有统计学意义(P<0.05).Pearson相关分析显示,ACI患者hsa_circ_0090231、hsa_circ_0004543表达均与 LDL-C 水平呈正相关(r=0.650、0.726,P<0.001).ROC 曲线显示,hsa_circ_0090231 的曲线下面积为 0.843 75(95%CI:0.736~0.939),特异度为0.875,灵敏度为0.700;hsa_circ_0004543的曲线下面积为0.968 75(95%CI:0.922~0.996),特异度为0.900,灵敏度为0.950.结论 hsa_circ_0090231和hsa_circ_0004543在ACI患者中表达激活,其在不良预后患者中表达高于预后良好者,且其对患者不良预后具有一定诊断价值.
Clinical significance of hsa_circ_0090231 and hsa_circ_0004543 in carotid artery plaques of patients with acute cerebral infarction
Objective To explore clinical significance of hsa_circ_0090231 and hsa_circ_0004543 in carotid artery plaques of patients with acute cerebral infarction(ACI).Methods Sixty patients with ACI admitted to the First Hospital of Jiaxing City in Zhejiang Province from January to De-cember 2022 were selected as the experimental group.According to prognosis,they were divided into the good prognosis group(39 cases)and the poor prognosis group(21 cases).Fifty healthy examinees underwent physical examinations at the medical examination center of the First Hospital of Jiaxing City in Zhejiang Province were selected as the control group during the same period.The expressions of hsa_circ_0090231 and hsa_circ_0004543 were determined by using real time quantitative polymerase chain reation.The correlation between hsa_circ_0090231,hsa_circ_0004543,and low-density lipoprotein cholesterol(LDL-C)were investigated by using Pearson analysis.Diagnostic efficacy of hsa circ_0090231 and hsa_circ_0004543 in predicting poor prognosis of patients with ACI were evaluated by using receiver operator characteristic(ROC)curve.Results The levels of hsa_circ_0090231,hsa_circ_0004543,and LDL-C in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).The levels of hsa_circ_0090231,hsa_circ_0004543,and LDL-C in the poor prognosis group were higher than those in the good prognosis group,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the expression of hsa_circ_0090231 and hsa_circ_0004543 in ACI patients was positively correlated with LDL-C levels(r=0.650,0.726,P<0.001).ROC curve showed that area under the curve of hsa_circ_0090231 was 0.843 75(95%CI:0.736-0.939),with a specifici-ty of 0.875 and a sensitivity of 0.700;area under the curve of hsa_circ_0004543 was 0.968 75(95%CI:0.922-0.996),with a specificity of 0.900 and a sensitivity of 0.950.Conclusion Hsa_circ_0090231 and hsa_circ_0004543 are expressed and activated in ACI patients,and their expression is higher in patients with poor prognosis than in those with good prognosis,and they have certain diagnostic value for poor prognosis in patients.

Acute cerebral infarctionCarotid plaqueHsa_circ_0090231Hsa_circ_004543

周虹、张小航、董雪、蒋健、邵平扬

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浙江省嘉兴市第一医院输血科,浙江嘉兴 314000

浙江省嘉兴市第一医院超声科,浙江嘉兴 314000

浙江省嘉兴市第一医院放射科,浙江嘉兴 314000

浙江省嘉兴市第一医院检验科,浙江嘉兴 314000

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急性脑梗死 颈动脉斑块 hsa_circ_0090231 hsa_circ_004543

浙江省基础公益研究计划项目浙江省嘉兴市科技计划项目浙江省嘉兴市第一医院市级医学重点学科建设经费资助项目

LGF21H0200062022AD300742023-ZC-002

2024

中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
年,卷(期):2024.21(18)