Therapeutic effect of caffeine combined with nasal intermittent positive pressure ventilation in transitional weaning of neonatal respiratory dis-tress syndrome
Objective To explore therapeutic effect of caffeine combined with nasal intermittent positive pressure ventilation(NIPPV)in transi-tional weaning of neonatal respiratory distress syndrome(NRDS).Methods A total of 44 children with NRDS received caffeine combined with NIP-PV treatment for transitional weaning in Fuyang People's Hospital of Anhui Province from February 2020 to July 2023 were prospectively selected as the observation group,43 children with NRDS received NIPPV treatment for transitional weaning were matched as the control group according to principle of propensity score matching.The Control group received NIPPV treatment,while the observation group received caffeine combined with NIPPV,treatment for two weeks.Treatment effects,blood routine related indicators,clinical related indicators,blood gas analysis indicators,and complications between two groups were compared.Results During treatment process,two cases fell out of each group,with 41 cases included in the control group the 42 cases included in the observation group.Treatment effect of the observation group was better than that of the control group,the difference was statistically significant(P＜0.05).After complete weaning for two weeks,white blood cell count(WBC)and C-reactive protein(CRP)levels in two groups were lower than immediately after complete weaning,percentages of neutrophils in two groups were higher than immedi-ately after complete weaning,and WBC and CRP levels in the observation group were lower than those in the control group,percentage of neu-trophils in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).Hospitalization time,oxygen therapy time,and NIPPV usage time of the observation group were shorter than those of the control group,restart rate of the observation group was lower than that of the control group,two-week weaning success rate of the observation group was higher than that of the control group,apnea times of the observation group was less than that of the control group,the differences were statistically significant(P＜0.05).After complete weaning for two weeks,pH value and arterial partial pressure of oxygen(PaO2)in two groups were higher than immediately after complete weaning,arterial partial pressure of carbon dioxide(PaCO2)in two groups were lower than immediately after complete weaning,PaO2 in the observation group was higher than that in the control group,PaCO2 in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in total incidence rate of complications between two groups(P＞0.05).Con-clusion Caffeine combined with NIPPV treatment during transitional weaning in children with NRDS can significantly improve their blood routine indicators,clinical indicators,and blood gas analysis indicators,with significant effects.
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