Effect of different hormone administration methods on endometrial metabolism and therapeutic effect in patients after transcervical resection of adhesions
Objective To investigate the effects of different hormone administration methods on endometrial metabolism and therapeutic effect in patients after transcervical resection of adhesions(TCRA).Methods A total of 65 patients with intrauterine adhesions(IUA)received TCRA treat-ment at Department of Gynaecology and Obstetrics of Jinhua Maternal and Child Health Care Hospital in Zhejiang Province from January to De-cember 2022 were selected as the study subjects.They were divided into the percutaneous estrogen group(22 cases),the oral estrogen group(22 cases)and the oral estrogen and progesterone group(21 cases)by using random number table method.The percutaneous estrogen group was treated with external application of Percutaneous Estradiol Gel,the oral estrogen group was treated with oral Estradiol Valerate Tablets,and the oral estrogen and progesterone group was treated with oral Estradiol Tablets/Estradiol Didroxyprogesterone Composite Tablets.All three groups were treated for two months.Endometrial metabolism,IUA score,therapeutic effect,and adverse reactions among three groups were compared.Results Before treatment,there were no statistically significant differences in endometrial thickness,resistance index,and pulsatility index among the three groups(P＞0.05).After treatment,endometrial thickness of the three groups was greater than before treatment,and resistance index and pulsatility index of the three groups were higher than before treatment,endometrial thickness of the oral estrogen and progesterone group was greater than that of the percutaneous estrogen group and the oral estrogen group,and the differences were statistically significant(P＜0.05).Before treatment,there were no statistically significant differences in IUA scores among the three groups(P＞0.05).After treatment,IUA scores of three groups were lower than before treatment,and the oral estrogen and progesterone group was lower than the percutaneous estrogen group and the oral estrogen group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total effective rate among the three groups(P＞0.05).There was no significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).Conclusion Oral estrogen and progesterone therapy for patients with IUA after TCRA can improve endometrial metabolism and promote endometrial repair.
Transcervical resection of adhesionsHormonesAdministration methodEndometrial metabolism
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