Effect of different use timing of caffeine citrate on apnea and prognosis in infants with ultra/very low birth weight
Objective To explore the effect of different use timing of caffeine citrate on apnea and prognosis in infants with ultra/very low birth weight.Methods A total of 64 premature infants with ultra/very low birth weight admitted to Fu Yang People's Hospital in Anhui Province from August 2019 to August 2022 were selected and divided into group A and group B by random number table method,with 32 cases in each group.Group A received treatment with caffeine citrate within three days of birth,while group B received treatment with caffeine citrate after three days of birth.Maintenance treatment time of caffeine citrate,the incidence rate of apnea after 24 hours of administration,non-invasive ventilator assisted ventilation time,mechanical ventilation time for invasive tracheal intubation,oxygen therapy time,complications and adverse reactions of the two groups were compared.Results Maintenance treatment time of caffeine citrate in group A was shorter than that in group B,the incidence rate of ap-nea after 24 hours of administration in group A was lower than that in group B,and the differences were statistically significant(P＜0.05).Non-in-vasive ventilator assisted ventilation time,mechanical ventilation time for invasive tracheal intubation and oxygen therapy time in group A were shorter than those in group B,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in the incidence rate of intracranial hemorrhage and necrotizing enterocolitis between the two groups(P＞0.05).The incidence rate of bronchopulmonary dysplasia and retinopathy of prematurity in group A were lower than those in group B,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in the incidence rate of vomiting,feeding difficulties and electrolyte disorders during treatment be-tween the two groups(P＞0.05).Conclusion Early application of caffeine citrate in the treatment of ultra/very low birth weight premature infants is more helpful to reduce the overall oxygen intake time of the children,as well as the incidence rate of apnea and the risk of bronchopulmonary dys-plasia and retinopathy of prematurity after administration,with good efficacy and no significant increase in adverse drug reactions.
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