Invasion and metastasis are important factors that make malignant tumors difficult to treat.ARHGDIB is involved in invasion and metastasis of various malignant tumors and is a class of important metastasis inhibitors.This article elaborates on involvement of ARHGDIB in multiple signaling pathways by regulating Rho GTPase,regulating invasion and metastasis of malignant tumors.ARHGDIB plays a role mainly through Rae pathway in bladder cancer,gastric cancer,and leukemia,while in lung cancer,liver cancer,and pancreatic ductal adenocarcinoma,its regulation of PI3K/PKB/Akt signaling pathway is more common.ARHGDIB inhibits metastasis of malignant tumors by regulating inflammatory response in tumor microenvironment.Therefore,it can play a role in different malignant tumors by regulating different signaling pathways.
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