Exploration on experience of Zhang Lei uses Chaihu classic prescriptions as Chinese medicine master based on data mining
Objective To explore experience of Zhang Lei uses Chaihu classic prescriptions as Chinese medicine master based on data mining,and provide reference for clinical application of classic prescriptions.Methods Medical cases of Zhang Lei's Collection of Clinical Experience,Zhang Lei's Complete Book of Medicine,Chinese Medical Master Zhang Lei Medical Library,and Chinese medical master Zhang Lei's Famous Medical Studio uses Chaihu classic prescriptions of Shanghan Lun from January 2018 to August 2022 were collected and organized.Input informations from multiple perspectives such as traditional Chinese medicine diseases,combined prescriptions of Chaihu classic and flavored drugs were analyzed by using WPS Excel 2023 and Traditional Chinese Medicine Inheritance Assistance Platform(V2.5)software.Results A total of 381 medical records and 500 cases were included,involving various diseases such as spleen and stomach disease syndrome,qi,blood and body fluid disease syndrome and liver and gallbladder disease syndrome.Prescriptions commonly paired with Chaihu classic prescriptions included Guizhi Decoction,Jinlingzi San,Yueju Wan,and so on.The commonly used medicinal properties were mainly warm and cold,and medicinal taste was mainly pungent,sweet,and bitter.Drugs mainly targeted spleen,stomach,lungs,liver,and gallbladder meridians.Flavored drugs mainly focused on clearing heat,promoting blood circulation and removing blood stasis.Top five most frequently used flavored drugs included Coicis Semen,Forsythiae Fructus,Lonicerae Japonicae Flos,Chuanxiong Rhizoma,and Corydalis Rhizoma.Eighteen core drug combinations obtained based on complex system entropy clustering.Conclusion Zhang Lei as master of traditional Chinese medicine mainly uses Chaihu classic prescriptions for Shaoyang disease.Zhang Lei increases or decreases medication based on characteristics of Shaoyang disease,such as easy to be threatened by pathogenic factors,easy to be lack of ministerial fire,easy to be qi and blood stasis,easy to be qi stagnation and fire,easy to involve taiyin,easy to produce phlegm and drink and easy to be complicated with taiyang yangming.Commonly used formulas include Guizhi Decoction,Jinlingzi San,Yueju Wan,and Jupi Zhuru Decoction.Commonly used medications include Coicis Semen,Lonicerae Japonicae Flos,Forsythiae Fructus,Chuanxiong Rhizoma,Corydalis Rhizoma,Curcumae Radix,Citri Reticulatae Pericarpium,Toosendan Fructus,and Atractylodis Macrocephalae Rhizoma,etc.
Data miningZhang Lei Chinese medicine masterChaihu classic prescriptionsExperience of famous doctors