Bidirectional Mendelian randomization study of the causal association between psoriasis and coronary heart disease
Objective To analyze whether there is a causal association between psoriasis and coronary heart disease(CHD)by bidirectional two-sample Mendelian randomization(MR)method.Methods The data used in this study were obtained from the genome-wide association analysis database.In the forward study,the single nucleotide polymorphisms(SNPs)associated with psoriasis were obtained as the instrumental variable,and CHD as outcome;in the reverse study,the SNPs associated with CHD were taken as instrumental variable,psoriasis as outcome.R 4.3.2 software was used to analyze the causal association between psoriasis and CHD by bidirectional two-sample MR analysis.The research methods included inverse variance weighted(IVW)method,MR-Egger regression method,weighted median method,simple mode method,and weighted mode method.Cochran's Q test and MR-Egger regression method were used to assess the heterogeneity of genetic instrumental variable,the MR-Egger intercept method was used to test the horizontal pleiotropy of the assessment,and the"leave-one-out method"was used to assess the sensitivity of a single SNP to the effect of causality.Results The forward study selected 28 SNPs associated with psoriasis for analysis,the results of fixed effect IVW method showed that there was a causal association between psoriasis and CHD(P＜0.05);MR-Egger regression method,weighted median method,weighted mode method supported this result.Cochran's Q test,MR-Egger regression method showed no heterogeneity;MR-Egger intercept method showed no horizontal pleiotropy;the"leave-one-out method"showed that a single SNP had no significant effect on causality in this study;and the funnel plot was largely symmetric and less biased.In the reverse study,8 SNPs related to CHD were selected for analysis,the result of the fixed effect IVW method showed that there was no causal relationship between CHD and the development of psoriasis(P＞0.05),and MR-Egger regression method,weighted median method,simple mode method,and weighted mode method support this result.Cochran's Q test,MR-Egger regression showed no heterogeneity;MR-Egger intercept showed no horizontal pleiotropy;the"leave-one-out"method showed that a single SNP had an effect on causality,probably related to the small number of SNPs included in the analysis,and the sensitivity analyse was dominated by the results of heterogeneity and horizontal pleiotropy;and the funnel plot was largely symmetric and less biased.Conclusion Psoriasis with CHD has positive causal relationship,which will increase the risk of CHD in patients with psoriasis.Early intervention for patients with a history of psoriasis may reduce the risk of CHD.
PsoriasisCoronary heart diseaseMendelian randomizationCausal association
NETL
NSTL
万方数据
