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基于数据挖掘分析中药治疗糖尿病合并血脂异常的用药规律

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目的 基于数据挖掘分析梁晓春教授治疗糖尿病合并血脂异常的组方特点,传承梁晓春教授临床治疗糖尿病合并血脂异常的学术思想。方法 应用回顾性真实世界研究方法,以北京协和医院信息系统的电子病历为载体,采集梁晓春教授2021年1月至2022年12月北京协和医院中医科门诊治疗糖尿病合并血脂异常患者的临床信息,构建数据库并将其录入中医传承计算平台(V 3。5),运用关联规则、聚类分析等方法分析病案处方的用药频次、性味归经、常用药物组合,总结梁晓春教授治疗糖尿病合并血脂异常的治则治法和用药规律。结果 共整理梁晓春教授治疗糖尿病合并血脂异常的验方559则,中药249味,使用次数最多的药物为桑白皮、鸭跖草、葛根、丹参、女贞子及荷叶等,性味多甘寒,归经多属于肝脾胃经。最核心的药物组合为葛根-丹参、桑白皮-葛根、桑白皮-鸭跖草、桑白皮-丹参、葛根-黄芪等。聚类分析得出4个核心处方为桑白皮-鸭跖草-荷叶-女贞子-葛根-姜黄、鸭跖草-桑白皮-葛根-丹参-女贞子-黄芪、桑白皮-鸭跖草-葛根-丹参-荷叶-黄芪、桑白皮-鸭跖草-黄芪-川芎-葛根-丹参。结论 梁晓春教授治疗糖尿病合并血脂异常以益气养阴、活血化瘀兼祛湿化浊为原则,用药经验体现了健脾、补肾治其本,活血祛瘀、祛湿化浊治其标的学术思想。
Analysis of medication rule of traditional Chinese medicine in treating diabetes with dyslipidemia based on data mining
Objective To analyze the prescription characteristics of professor Liang Xiaochun in the treatment of diabetes mellitus complicated with dyslipidemia,and to inherit Professor Liang Xiaochun's academic idea of clinical treatment of diabetes with dyslipidemia.Methods The retrospective real world study research method was used to collect the clinical information of Professor Liang Xiaochun on the treatment of patients complicated with dyslipidemia treated in the outpatient Department of Traditional Chinese Medicine of Peking Union Medical College Hospital from January 2021 to December 2022 was collected,and the database was constructed and recorded into the traditional Chinese Medicine Inheritance Computing Platform(V3.5).Association rules,cluster analysis and other methods were used to analyze the frequency of medication,the normalization of sex and taste,and the combination of commonly used drugs,and the treatment rules and medication rules of Professor Liang Xiaochun in the treatment of diabetes mellitus complicated with dyslipidemia were summarized.Results A total of 559 prescriptions for Professor Liang Xiaochun's treatment of diabetes complicated with dyslipidemia were sorted out,including 249 traditional Chinese medicines.The most frequently used drugs were Mori Cortex,Commelinaeherba,Puerariae Lobatae Radix,Salviae Miltior-rhizae Radix Et Rhizoma,Ligustri Lucidi Fructus,Nelumbinis Folium and so on.The core drug combinations were Puerariae Lobatae Radix-Salviae Miltiorrhizae Radix Et Rhizoma,Mori Cortex-Puerariae Lobatae Radix,Mori Cortex-Commelinaeherba,Mori Cortex-Salviae Miltiorrhizae Radix Et Rhizoma,Puerariae Lobatae Radix-Astragali Radix and so on.The cluster analysis showed that the four core prescriptions were Mori Cortex-Commelinaeherba-Nelumbinis Folium-Ligustri Lucidi Fructus-Puerariae Lobatae Radix-Curcumae Longae Rhizoma,Commelinaeherba-Mori Cortex-Puerariae Lobatae Radix-Salviae Miltiorrhizae Radix Et Rhizoma-Ligustri Lucidi Fructus-Astragali Radix,Mori Corte-Commelinaeherba-Puerariae Lobatae Radix-Salviae Miltiorrhizae Radix Et Rhizoma-Nelumbinis Folium-Astragali Radix,Mori Cortex-Commelinaeherba-Astragali Radix-Chuanxiong Rhizoma-Puerariae LobataE Radix-Salviae Miltiorrhizae Radix Et Rhizoma.Conclusion Professor Liang Xiaochun's treatment of diabetes complicated with dyslipidemia is based on the principle of supplementing qi and yin,promoting blood circulation to remove blood stasis and removing dampness and turbidity.His medication experience reflects the academic idea of strengthening the spleen,tonifying the kidney to treat the root,promoting blood circulation to remove blood stasis,removing dampness and turbidity to treat the target.

Diabetes mellitus complicated with dyslipidemiaReal world studyData miningMedication experienceLiang Xiaochun

景光婵、李耀洋、杨丹、吴群励

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中国医学科学院北京协和医院中医科,北京 100730

糖尿病合并血脂异常 真实世界研究 数据挖掘 用药经验 梁晓春

国家中医药管理局青年岐黄学者培养项目北京协和医院中央高水平医院临床科研专项青年培优计划项目

国中医药人教函[2022]256号2022-PUMCH-A-211

2024

中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
年,卷(期):2024.21(20)