Research progress on anti-liver cancer activity and mechanism of action of toxic traditional Chinese medicine
Liver cancer is malignant tumor with high incidence rate and mortality.Toxic traditional Chinese medicine refers to a type of Chinese medicine with strong properties,therapeutic dose close to toxic dose,and improper use that can cause serious damage to the human body,even death.Toxic traditional Chinese medicines with anti-liver cancer effects reported in the past five years include heat-clearing and detoxicating drugs such as Bruceae Fructus and Paridis Rhizoma,phlegm-resolving,mass-resolving drugs such as Pinelliae Rhizoma and Arisaematis Rhizoma,qi-promoting and pain-relieving drugs such as Toosendan Fructus,blood-activating and blood-stasis-dissolving drugs such as Strychni Semen and Mylabris,dampness-removing drugs such as Tripterygium Wilfordii and Aconitum Carmichaeli,antiviral and insecticidal drugs such as Cnidii Fructus,Bufonis Venenum and White Arsenic,detoxifying and mass-resolving drugs such as Phytolaccae Radix,blood breaking and symptom eliminating drugs such as Euphorbiae Semen,relieving depress liver drugs such as Euodiae Fructus.Pharmacological studies have shown that toxic traditional Chinese medicine can effectively exert anti-liver cancer effects,which can be achieved through mechanisms such as cell cycle arrest,induction of cell apoptosis,anti-tumor angiogenesis,inhibition of cell invasion and migration,etc.This article aims to summarize anti-liver cancer activity and mechanism of action of toxic traditional Chinese medicine in the past five years,providing reference for further research by industry scholars.
Toxic traditional Chinese medicineLiver cancerMechanism of actionResearch progress
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