Discussion on the medication experience of Professor Hua Baojin in the treatment of post-operative colorectal cancer by the method of regulating qi and drying dampness based on data mining
Objective To summarize the medication experience of Professor Hua Baojin in the treatment of patients with colorectal cancer after radical resection.Methods A total of 199 patients with colorectal cancer after radical resection who were treated in Professor Hua Baojin's clinic from October 2022 to October 2023 in Guang anmen Hospital of China A-cademy of Chinese Medical Sciences were included,and a total of 464 prescriptions were included in the study.A database was set up,and data mining was performed by SPSS Modeler 18.0 and SPSS Statistics 26.0 software to analyze the frequency of drug types,the medication frequency,natures,and flavors,efficacy,rules of association,complex networks,and core med-ications of Professor Baojin Hua's medication for post-opera-tive of colorectal cancer.Results The number of prescriptions for each dose of 464 prescriptions ranged from 14 to 39,with an average of 26.A total of 235 drugs were used in 464 pre-scriptions,and the accumulative drug frequency was 12 109.The Atractylodes macrocephala Rhizoma was the herb used Most frequently,"plain"was the drug property used most frequently,"sweet"was the medicinal ingredients used most fre-quently,and the meridians of drug were concentrated in the spleen meridian,stomach meridian,and liver meridian.The supplementing drugs was the drug category frequency used most frequently.The association rules,complex networks,and core drug clustering yielded the medicine pair included Poria-Atractylodis Macrocephalae Rhizoma,Actinidia chinensis Planch-Duchesnea indica(Andrews),Aucklandiae Radix-Amomi Fructus,and 18 clustering formulae.Conclusion In the treatment of post-operative colorectal cancer,Professor Hua Baojin takes deficiency in root(qi)and excess in branch(damp,heat)as the basic pathogensis,and uses the method of"regulating qi and drying dampness"as guidance,especially empha-sizing the regulating ascending and descending of qi movement.The treatment is based on different syndromes and the med-ication is appropriate and calm,which provides certain guiding value for the clinical treatment of patients with colorectal cancer.
Data miningColorectal cancerRegulating qi and drying dampnessHua BaojinExperience
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