Research progress on the role of bone morphogenetic protein 2 in regulating dental sac osteogenic differentiation during tooth eruption
As a necessary organ for tooth eruption,dental sac play an important role in inducing osteogenic/osteoclast differentiation and promoting the formation of eruption channels.Bone morphogenetic protein 2(BMP2)is a multifunctional morphological factor with high osteoinductive activity,mainly mediating the differentiation of dental sac cell into osteoblasts through autocrine or paracrine forms.In recent years,research on BMP2 promoting alveolar bone remodeling by regulating dental sac osteogenic differentiation and ensuring the normal formation of tooth eruption channels has increasingly attracted the attention of many scholars.However,the specific mechanism is still unclear.This article reviews biological properties of BMP2 and its possible mechanism of co-regulating dental sac osteogenic differentiation through its interaction with multiple signaling pathways.The aim is to provide new theoretical basis for expanding the research on molecular regulatory mechanisms during tooth eruption from the perspective of bone metabolism and preventing and treating tooth eruption disorders.
Bone morphogenetic protein 2Dental sacOsteogenic differentiationTooth eruption
NETL
NSTL
万方数据
