Research progress of chemotherapy-free radiation therapy combined with immune checkpoint inhibitors in the treatment of locally advanced non-small cell lung cancer
For patients with unresectable locally advanced non-small cell lung cancer(LA-NSCLC),maintenance of immune checkpoint inhibitors after concomitant radiochemotherapy remains the standard treatment regimen.Some LA-NSCLC patients are not suitable for chemotherapy due to various reasons,manifested in the need for no chemotherapy regimen in the selection of treatment plans.Recent studies have shown that radiation therapy combined with immune checkpoint inhibitors have good synergistic effects and potential therapeutic value as a treatment strategy.This article mainly provides systematic summary of chemotherapy-free radiation therapy combined with immune checkpoint inhibitors in the treatment of unresectable LA-NSCLC,which helps to better understand mechanism,advantages,and limitations of this treatment mode,and provides more targeted guidance for clinical practice.
Chemotherapy-free regimenRadiotherapyImmune checkpoint inhibitorsLocally advanced non-small cell lung cancer
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