Clinical effect of Xuefu Zhuyu Decoction in treating patients with early awakening type insomnia and its effect on cerebral haemodynamics
Objective To observe the clinical effect of Xuefu Zhuyu Decoction in treating patients with early awakening type insomnia and its effect on cerebral haemodynamics.Methods Sixty insomnia patients treated in Liuzhou Traditional Chinese Medicine Hospital,Guangxi Zhuang Autonomous Region from May 2021 to May 2023 were selected and they were divided into treatment group and control group according to random number table method,with 30 cases in each group.The treatment group was treated with Xuefu Zhuyu Decoction for two weeks,and the control group was treated with Alprazolam Tablets for two weeks.Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),and dysfunctional beliefs and attitudes about sleep(DBAS)scores of the two groups were compared before and after treatment.Transcranial colour Doppler ultrasound was used to observe the changes in the blood flow velocity of vertebrobasilar artery before and after treatment in the two groups,and and the clinical effects of the two groups at the same time were compared.Results After treatment,sleep quality,time to fall asleep,sleep duration,sleep efficiency,sleep disturbance,daytime functioning,and total scores were lower in both groups than before treatment,and sleep quality,sleep duration,sleep efficiency,daytime functioning,and total scores were lower in the treatment group than in the control group(P＜0.05).After treatment,the ISI scores of both groups decreased compared with those before treatment,and the scores of the treatment group were lower than those of the control group(P＜0.05).After treatment,the estimated consequences of insomnia,insomnia worry,sleep expectancy,drug dependence,and total scores of both groups were higher than those before treatment,and the estimated consequences of insomnia,insomnia worry,and total scores of the treatment group were higher than those of the control group(P＜0.05).After treatment,vertebral artery systolic peak flow velocity,basilar artery systolic peak flow velocity,vertebral artery mean blood flow velocity,and basilar artery mean blood flow velocity were higher than before treatment in both groups,and vertebral artery systolic peak flow velocity and basilar artery systolie peak flow velocity of the treatment group were higher than those of the control group(P＜0.05).There was no significant difference in clinical efficacy between the two groups(P＞0.05).Conclusion For patients with insomnia with early awakening type,Xuefu Zhuyu Decoction can effectively improve the quality of sleep,reduce the accompanying symptoms and enhance daytime functioning,as well as alleviate the fear and worry of insomnia,and at the same time,it can effectively improve the cerebral blood flow dynamics of the patients.
InsomniaSix meridians when the disease desires to be resolvedXuefu Zhuyu DecoctionTranscranial DopplerAlprazolam
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