Comparative analysis of intestinal flora and intestinal mucosal barrier function in children with pertussis and pertussis-like syndrome
Objective To explore the differences in clinical characteristics,intestinal flora,and intestinal mucosal barrier function in children with pertussis and pertussis-like syndrome.Methods Forty cases of children diagnosed with pertussis who had attended the First Affiliated Hospital of Hebei North University from January 2020 to December 2023 were selected as the pertussis group,while 43 cases of children with pertussis-like syndrome during the same period were selected as the pertussis-like group.The differences in clinical characteristics,intestinal mucosal barrier function,and intestinal flora between the two groups were compared;and the correlation between clinical characteristics,intestinal flora,and intestinal mucosal barrier function were analyzed.Results The percentage of pertussis vaccination in the pertussis group was lower than that in the pertussis-like group,while the percentage of cyanosis,white blood cell count(WBC),and lymphocyte percentages were higher than those in the pertussis-like group(P＜0.05).Intestinal Bifidobacterium and Lactobacillus counts in the pertussis group were lower than those in the pertussis-like group,while Escherichia coli counts were higher than those in the pertussis-like group(P＜0.05).The levels of D-lactic acid(D-LA)and diamine oxidase(DAO)in the pertussis group were higher than those in pertussis-like syndrome group(P＜0.05).In the pertussis group,cyanosis,WBC,lymphocyte percentage,and Escherichia coli counts were positively correlated with the levels of D-LA and DAO(rs/r＞0,P＜0.05);pertussis vaccination history,Bifidobacterium and Lactobacillus counts were negatively correlated with the levels of D-LA and DAO(rs/r＜0,P＜0.05).In pertussis-like group,cyanosis,WBC,lymphocyte percentage,and Escherichia coli counts were positively correlated with the levels D-LA and DAO(rs/r＞0,P＜0.05);Bifidobacterium and Lactobacillus counts were negatively correlated with the levels of D-LA and DAO(rs/r＜0,P＜0.05).Conclusion Compared with pertuss-like syndrome,children with pertussis have a lower proportion of pertussis vaccination,higher percentage of WBC and lymphocytes percentage,an imbalance of intestinal flora,and an impaired intestinal mucosal barrier.
PertussisPertussis-like syndromeIntestinal floraIntestinal mucosal barrier function
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