Clinical efficacy of Cyclosporine Eye Drops combined with Diquafosol Sodium Eye Drops in the treatment of moderate or severe dry eye associated with Sj?gren's syndrome
Objective To investigate the therapeutic effect of Cyclosporine Eye Drops combined with Diquafosol Sodium Eye Drops in patients with Sjögren's syndrome associated with moderate or severe dry eye.Methods Ninety patients(90 eyes)with Sjögren's syndrome associated with moderate or severe dry eye diagnosed by the Department of Rheumatology and Ophthalmology,the Affiliated Hospital of Xuzhou Medical University from October 2023 to January 2024 were selected for the study.They were divided into CsA group,DQS group,and combined group by random number table method,with 30 cases(30 eyes)in each group.In CsA group,0.05％Cyclosporin Eye Drops and 0.3％Sodium Hyaluronate Eye Drops were applied to both eyes.In DQS group,both eyes were injected with Diquafosol Sodium Eye Drops and 0.3％Sodium Hyaluronate Eye Drops.Combined group treated with combined medication.Treatment for 12 weeks.Before treatment,ocular surface disease index(OSDI)score,non-invasive tear meniscus height(NITMH),first non-invasive tear film break-up time(NIBUTf),meibomian gland loss score,red eye analysis,and corneal staining score were compared among the three groups at 2,4,and 12 weeks after treatment.Results OSDI score:after 2,4,and 12 weeks of treatment,the three groups were lower than before treatment(P＜0.05);the CsA group and the combined group after 4 and 12 weeks of treatment were lower than after 2 weeks of treatment.After 12 weeks of treatment,the combined group was lower than DQS group and CsA group(P＜0.05).NITMH score:after 12 weeks of treatment,the three groups were higher than before treatment,and the difference was statistically significant at each time point after 2,4,and 12 weeks of treatment in the combined group(P＜0.05).After 4 weeks of treatment in CsA group was higher than before treatment,after 12 weeks of treatment in DQS group was higher than after2weeks of treatment(P＜0.05).After4 and 12 weeks of treatment,the combined group was higher than the DQS group(P＜0.05).NIBUTf score:there were statistically significant differences between combined group and CsA group at each time point(P＜0.05).The DQS group after 12 weeks of treatment was higher than before and after 2 weeks of treatment(P＜0.05).After 4 and 12 weeks of treatment,the combined group was higher than DQS group and CsA group(P＜0.05);after 2 weeks of treatment,the combined group was higher than the DQS group(P＜0.05).Lipid layer thickness grading score:After 2,4,and 12 weeks of treatment the combined group was higher than before treatment;there was statistical significance at each time point in CsA group(P＜0.05).The DQS group after 12 weeks of treatment was higher than that before and after 2 weeks of treatment(P＜0.05).There was no significant difference between the combined group,DQS group and CsA group at each time point(P＞0.05).The lipid layer thickness grading score:after 12 weeks of treatment,the combined group was higher than that before and after 2 and 4 weeks of treatment,and after 2 and 4 weeks of treatment were higher than before treatment(P＜0.05).The CsA group was higher after 12 weeks than before and after 4 weeks,after 4 weeks was higher than after 2 weeks of treatment,and after 2 weeks of treatment was higher than before treatment(P＜0.05).The DQS group after 12 weeks of treatment was higher than before and after 2 weeks of treatment(P＜0.05).Conjunctival grade score:there were statistically significant differences between combined group and CsA group at each time point(P＜0.05).The DQS group after 12 weeks of treatment was lower than that after 2 weeks of treatment(P＜0.05).After 4 and 12 weeks of treatment,the combined group was lower than DQS group and CsA group(P＜0.05).Corneal staining score:after 12 weeks of treatment,the score of the three groups was lower than before treatment,and after 2 and 4 weeks of treatment,and after 4 weeks of treatment,the score of the three groups was lower than before treatment and after 2 weeks of treatment(P＜0.05).After 2 weeks of treatment,the combined group was lower than before treatment(P＜0.05).At 2,4 and 12 weeks after treatment,the corneal staining score in combined group was lower than that in DQS and CsA group(P＜0.05).Conclusion Cyclosporine Eye Drops combined with Desquafoxol Sodium Eye Drops can significantly improve the objective signs and symptoms of patients with dry eye,continuously improve the time of tear film rupture,and have good clinical practicability.
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