Research progress on the mechanism of renal tubular injury caused by hyperuricemia
Uric acid is the final product of purine metabolism in the human body.When uric acid is produced too much or excreted is reduced,excessive accumulation of uric acid in the body can lead to hyperuricemia.Hyperuricemia is considered to be an independent risk factor for kidney damage and chronic kidney disease.When the concentration of uric acid exceeds the normal physiological range,it can cause a variety of pathological reactions in the renal tubules,but its pathophysiological mechanism is not fully understood.This article reviews the molecular mechanisms of renal tubular damage caused by hyperuricemia,including autophagy,inflammation,oxidative stress,apoptosis,epithelial-mesenchymal transition,fibrosis,and other processes induced by uric acid in hyperuricemia.