Prognostic significance of dynamic monitoring of B-type natriuretic peptide,D-dimer,and serum albumin to globulin ratio in patients with acute exacerbations of chronic obstructive pulmonary disease
Objective To investigate the value of serum B-type natriuretic peptide(BNP),D-dimer(D-D),and albumin-to-globulin ratio(AGR)in predicting the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 162 patients with AECOPD hospitalized in Chaohu Hospital of Anhui Medical University from January 2021 to April 2023 were selected as the study subjects.They were divided into the poor prognosis group(64 cases)and the good prognosis group(98 cases)based on their prognosis within one year of treatment.The general clinical data of the two groups were recorded and analyzed,and multivariate logistic regression analysis was used to analyze the influencing factors of poor prognosis in AECOPD patients.Results The proportion of patients with a smoking history in the poor prognosis group was higher than that in the good prognosis group(P＜0.05).Serum BNP and D-D levels were lower on the 7th day of admission than on the 1st day,and AGR levels were higher than the 1st day(P＜0.05).The BNP and D-D levels in the poor prognosis group were higher than those the good prognosis group,while the AGR level was lower than that in the good prognosis group(P＜0.05).Multivariate logistic regression analysis identified smoking history(OR=4.125,95％CI:1.632-10.428,P=0.003),low serum AGR(OR=0.008,95％CI:0.001-0.071,P＜0.001),and high BNP(OR=1.097,95％CI:1.045-1.151,P＜0.001),and high D-D(OR=46.669,95％CI:5.374-405.269,P＜0.001)on the first day of admission as major risk factors for poor prognosis.Pearson correlation analysis showed that serum BNP(r=0.376,P＜0.001)and D-D level(r=0.351,P＜0.001)on the first day of admission were positively correlated with poor prognosis in AECOPD patients,while AGR(r=-0.296,P＜0.001)on the first day of admission was negatively associated with poor prognosis in AECOPD patients.ROC curve analysis indicated that the combined prediction of serum BNP,D-D,and AGR levels on the first day of admission for poor prognosis in AECOPD patients had a higher AUC than any single indicator(P＜0.05).Conclusion Dynamic monitoring of serum BNP,D-D,and AGR levels is of great significance for predicting the prognosis of AECOPD patients,particularly the early prediction value of these serum indicators at the initial stage of admission.
Dynamic monitoringB type natriuretic peptideD-dimerSerum albumin to globulin ratioAcute exacerbation of chronic obstructive pulmonary diseasePredictive value
万方数据
维普
