Study on medication pattern of traditional Chinese medicine compound based on national patents in the treatment of deep vein thrombosis in the lower limbs
Objective To analyze national patent Chinese medicine compound prescriptions through data mining method,and to explore the medication pattern of lower extremity deep vein thrombosis(DVT),and providing reference for clinical prescription and medication selection.Methods The patents of traditional Chinese medicine compound in the treatment of DVT were searched in the interface of China Patent Publication Bulletin within the website of the State Intellectual Property Office.The search time was from the establishment of the database to March 2024.Excel was used for frequency statistics.SPSS Modeler 18.0 software and traditional Chinese medicine inheritance support platform(V 2.5)were used for association rule and system clustering analysis,respectively.High-frequency traditional Chinese medicine was summarized,the four qi,five flavors,and meridians distribution of compound were analyzed,and the core combination of traditional Chinese medicine was explored.Results A total of 25 patents had been included,involving 128 traditional Chinese medicines.The top three most frequently occurring single drugs were Angelicae Sinensis Radix,Carthami Flos and Notoginseng Radix Et Rhizoma.The four qi were mainly warm,the five flavors were mainly bitter,spicy,and sweet,and the meridians were mainly liver,heart and spleen.In association rules,commonly used medicine pairs included Carthami Flos-Angelicae Sinensis Radix,Angelicae Sinensis Radix-Notoginseng Radix Et Rhizoma,while commonly used corner medicines included Carthami Flos-Persicae Semen-Angelicae Sinensis Radix,Carthami Flos-Angelicae Sinensis Radix-Notoginseng Radix Et Rhizoma.The correlation was set to nine and the penalty was set to four,resulting in 15 core combinations of three drugs.The entropy hierarchical clustering algorithm was used to obtain a total of 10 sets of new clustering combinations.After re-clustering,five new prescriptions for treating lower limb DVT were obtained.Conclusion Chinese medicine compound prescriptions in the treatment of DVT are mostly based on the therapeutic principles of activating blood circulation,clearing collaterals and removing dampness,treating the disease at its root and taking both the symptoms and the root cause into account.By exploring hidden patterns,new prescriptions for treating DVT are obtained,providing new ideas for clinical treatment.
Deep vein thrombosisData miningMedication patternTraditional Chinese medicine inheritance support platform
万方数据
维普
