Chronic hepatitis B is major public health problem that poses a global threat.Currently,the use of drugs in clinical practice can temporarily control progression of the disease,enabling a small number of patients to achieve"functional cure".The reason why chronic hepatitis B has not been cured for a long time is the result of immune tolerance of the body against hepatitis B virus.Destroying immune tolerance environment and restoring specific immune responses can help immune system clear hepatitis B virus,achieving"functional cure".Therapeutic vaccine of hepatitis B based on viral vectors has great effect in inducing human body to produce hepatitis B virus specific T cells.This article mainly reviews research progress of hepatitis B therapeutic vaccine based on viral vector at home and abroad in recent years.
关键词
乙型肝炎病毒/治疗性疫苗/病毒载体
Key words
Hepatitis B virus/Therapeutic vaccines/Virus vector
维普
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