Medication patterns and mechanisms analysis of Professor Liu Xin in the treatment of pulmonary nodules based on data mining and network pharmacology
Objective To analyze prescription medication patterns and core drug combination mechanisms of Professor Liu Xin in the treatment of pulmonary nodules based on data mining and network pharmacology.Methods A total of 198 prescriptions of pulmonary nodule patients visited Professor Liu Xin's Outpatient of Traditional Chinese Medicine Department at the First Affiliated Hospital of University of South China from January 2020 to January 2022 were collected.The medication patterns of four qi,five flavors,meridian tropism,core drug combinations,potential new drug combinations,and new prescriptions were explored by using traditional Chinese medicine inheritance assistance platform(V 2.5).The effective ingredients,targets,pathways,and other mechanisms of core drug combinations were predicted by using network pharmacology methods.Results Among 198 prescriptions,163 traditional Chinese medicines were involved,the majority of medicinal properties were warm,calm,and cold,the majority of medicinal flavors were sweet,spicy,and bitter,the main meridians were lung meridian,liver meridian,spleen meridian,and heart meridian.High-frequency drug combinations included Glycyrrhizae Radix Et Rhizoma-Platycodonis Radix,Glycyrrhizae Radix Et Rhizoma-Greater Selaginella,etc.The core drugs included Bupleuri Radix,Rehmanniae Radix,Cyathulae Radix,Angelicae Sinensis Radix,Carthami Flos,Persicae Semen,Paeoniae Radix Rubra,Platycodonis Radix,Aurantii Fructus,Chuanxiong Rhizoma,Glycyrrhizae Radix Et Rhizoma,Fritillariae Thunbergii Bulbus,Mori Cortex,Salvia Chinensis and Greater Selagine lla,resulted in 10 potential new drug combinations and five new prescriptions.Network pharmacology analysis showed that the effective components of core drug combination in the treatment of pulmonary nodules were quercetin,kaempferol,etc.,which regulated AGE-RAGE,TNF,IL-17,HIF-1,PI3K-Akt,and FoxO signaling pathway by acting on TP53,Akt1 and JUN targets.Conclusion Professor Liu Xin in the treatment of pulmonary nodules mainly focuses on promoting blood circulation and removing blood stasis,soothing liver and regulating qi,resolving phlegm and dispersing nodules,and warming lungs and resolving yin,while also strengthening spleen and tonifying kidneys.This reflects his academic characteristics based on"dragon and tiger circle"theory and"treating from liver"pulmonary nodules,and proposes potential new drug combinations and prescriptions,providing new ideas for clinical treatment of pulmonary nodules.The potential targets and mechanisms of core drug combination therapy for pulmonary nodules mainly participate in biological processes such as inflammation,angiogenesis,cell proliferation and apoptosis,providing reference for further research on mechanisms of action.
Pulmonary nodulesMedication patternsData miningNetwork pharmacologyMechanism of actionExperience of famous doctor
万方数据
维普
