Meta-analysis of risk factors for post-intensive care syndrome in severely traumatized patients
Objective To systematically review the risk factors for post-intensive care syndrome(PICS)in severely traumatized patients.Methods PubMed,Medline,Web of Science,Cochrane Library,CNKI,Wanfang Data,VIP,and China Biomedical Literature Database were searched to collect relevant literatures on the risk factors for PICS syndrome in severely traumatized patients.The retrieval period was from January 2010 to April 2024.Literature screening and data extraction were performed independently by two investigators.Literature quality was evaluated using the Newcastle-Ottawa scale(NOS)for included cohort and case-control studies,and the agency for healthcare and quality(AHRQ)criteria for cross-sectional studies,and meta-analyses were performed using the RevMan 5.4 and Stata 18.0 software.Results A total of 11 literatures were included,seven of them were cross-sectional studies and four were case-control studies,all of which were of moderate to high quality.Meta-analysis results showed that age ≥ 60 years(OR=1.66,95％CI:1.43-1.91,P＜0.001),smoking(OR=5.45,95％CI:1.61-18.47,P=0.006),alcohol consumption(OR=6.90,95％CI:2.14-22.26,P=0.001),length of stay in the ICU ≥7 days(OR=2.45,95％CI:1.18-5.11,P=0.020),mechanical ventilation therapy(OR=1.96,95％CI:1.04-3.68,P=0.040),sleep disorders(Oβ=2.78,95％CI:1.35-5.73,P=0.005),sedative medication use(OR=2.88,95％CI:1.34-6.22,P=0.007)were independent risk factors for PICS syndrome in severely traumatized patients.The results of sensitivity and publication bias analyses showed that,except for the factors of age ≥ 60 years and length of stay in the ICU ≥7 days,the other factors suggested that the results of the analyses were reliable,and the presence of publication bias was less likely.Conclusion There are numerous risk factors for the occurrence of post-ICU syndrome in severely traumatized patients,and in clinical practice healthcare professionals should focus on their high-risk groups and provide timely assessment and intervention for these risk factors in order to reduce the incidence of post-ICU syndrome in critically traumatized patients,and to better promote patients'healthy regression.
TraumaCritical carePost-intensive care syndromeRisk factorsMeta-analysis
万方数据
维普
