Exploring the formulation rules of patent traditional Chinese medicine compound in the treatment of ankylosing spondylitis based on data mining method
Objective To explore traditional Chinese medicine treatment of ankylosing spondylitis(AS)of drug and formula based on the national patent traditional Chinese medicine compound.Methods The data of the patented traditional Chinese medicine compound for the treatment of AS were retrieved from the database of China Patent Publication Network of the State Intellectual Property Office from the inception to May,2024.Microsoft Office Excel 2010 and the Traditional Chinese Medicine Inheritance Platform V 2.5 were used for carry out the statistics of frequency,nature,flavour,and channel tropism of Chinese medicine,and the results were analyzed and visualized by association rules and systematic cluster analysis,and the results were combined with new formulas.Results A total of 194 patent compounds were included,involving five patent compounds shared internally and externally,and 149 effective traditional Chinese medicine compounds were obtained after excluding prescriptions containing the same drug in traditional Chinese medicine compounds,with involving 531 kinds of drugs.The top 20 were mainly Chinese Angelicae Sinensis Radix,Cibotii Rhizoma,Glycyrrhizae Radix Et Rhizoma,Eu-commiae Cortex,Spatholobi Caulis,Achyranthis Bidentatae Radix,Angelicae Pubescentis Radix,Paeoniae Radix Alba,Clematidis Radix Et Rhizoma,Taxilli Herba,Rehmanniae Radix Praeparata,Dipsaci Radix,Rhizoma Ligustici Chuanx-iong,Cinnamomi Ramulus,Astragalus propinquus,Carthami Flos,Notopterygii Rhizoma Et Radix,Eupolyphaga Stele-ophaga,Saposhnikoviae Radix,Salviae Miltiorrhizae Radix Et Rhizoma.The nature of drug was mainly warm,cold,and mild,the flavour of drug was mostly sweet,bitter,and pungent.Which belonged to mostly liver,kidney,and spleen meridians.Association rules analysis obtained 12 groups of high frequency drug combinations and based on the support degree was set to 20,and the confidence level was 0.6,including 10 traditional Chinese medicines(frequency ≥ 20),which were ranked in descending order as"Eucommiae Cortex-Cibotii Rhizoma","Paeoniae Radix Alba-Cibotii Rhizoma","Eucommiae Cor-tex-Angelicae Sinensis Radix",etc.Six closely related drug combinations were obtained,which were ranked in descending order as"Paeoniae Radix Alba-Cibotii Rhizoma","Dipsaci Radix-Cibotii Rhizoma","Rehmanniae Radix Praeparata-Angelicae Sinensis Radix"and so on.Using unsupervised entropy hierarchical clustering algorithm,14 groups of new for-mula core combinations were obtained,and seven potential new methods were obtained on this basis.Conclusion The main therapeutic methods of the patented Chinese medicine compound in the treatment of AS are tonifying liver and kidney,in-vigorating spleen eliminating dampness and promoting blood circulation for removing blood stasis and relieving pain.This study analyzes the formula rules of the patented traditional Chinese medicine compound for the treatment of AS,which pro-vides a certain reference for the formulation and new drugs development for the treatment of AS in clinical practice.
Ankylosing spondylitisData miningTraditional Chinese medicine inheritance assistance systemChinese medicine compoundPatents
NETL
NSTL
万方数据
