Research progress of myopic scleral remodeling and its intervention methods
Myopia is the most common refractive error.Changes in extracellular matrix composition of sclera can cause scleral remodeling,which affects biomechanical properties of sclera,and any biomechanical changes may lead to refractive errors.The incidence of myopia is increasing at an epidemic rate and has become a global public health problem.Scleral remodeling is a dynamic and complex process.Retinoic acid,matrix metalloproteinases,hypoxia-inducible factor-1 α and other factors and signaling pathways have been confirmed to participate in and regulate scleral remodeling.This article reviews the relevant factors,signal transduction pathways,existing intervention methods,and targets that currently affect myopia scleral remodeling,providing new ideas for myopia prevention and treatment.
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