Research progress on the association between RELN gene and schizophrenia
Schizophrenia(SCZ)is a serious and complex mental disorder that has a significant impact on public health,and its etiology has not been fully elucidated yet.It may be related to various factors such as genetics,environment,and abnormalities in neurodevelopment.RELN gene is located on chromosome 7q22.1 in humans,encoding a serine protein RELN in extracellular matrix.This protein is synthesized in cerebral cortex and hippocampus,and is involved in neuronal migration and the development of cerebral cortex.Abnormalities in RELN and its signaling pathway may limit dendritic proliferation,affect neurogenesis,and synaptic transmission,leading to cognitive deficits and brain morphological abnormalities.Previous studies based on diverse populations and animal experiments have indicated that RELN gene is an important candidate gene for SCZ.This article reviews functional characteristics of RELN,genetic polymorphisms,and research progress on its role in the development of SCZ,aiming to further elucidate the potential role of RELN gene in the pathogenesis of SCZ and provide new insights for diagnosis and treatment of SCZ.