循环游离DNA在肾脏疾病中的研究进展
Research progress of circulating free DNA in kidney diseases
王学良 1苑书婷 1李甜 1席春生2
作者信息
- 1. 甘肃中医药大学第一临床医学院,甘肃兰州 730000
- 2. 中国人民解放军联勤保障部队第九四○医院肾脏病科,甘肃兰州 730050
- 折叠
摘要
肾脏疾病是一类严重威胁人类健康的疾病,其发病率及死亡率高,寻求高灵敏度的生物学指标有助于早期诊断和改善预后.循环游离DNA是一类存在于血浆、尿液及其他体液中游离于细胞外的双链DNA片段.循环游离DNA参与机体内在的炎症反应和凝血过程,在肾脏疾病中显著升高,可作为肾脏疾病的潜在生物标志物,对疾病的诊断和预后有重大意义.本文对循环游离DNA的生物学特性、在肾脏疾病中的作用及应用进展进行综述,以期为肾脏疾病的早期诊断及预后提供参考.
Abstract
Kidney disease is a kind of disease that seriously threatens human health,its incidence rate and mortality rate are high,seeking high sensitive biological indicators is helpful to early diagnosis and improve prognosis.Circulating free DNA is a type of double stranded DNA fragment that exists outside of cells in plasma,urine,and other body fluids.Circulating free DNA is involved in the body's intrinsic inflammatory response and coagulation process,and is significantly elevated in kidney disease,which can used as a potential biomarker for kidney disease and has significant implications for disease diagnosis and prognosis.This article reviews biological characteristics role and application progress in kidney diseases of circulating free DNA,in order to provide reference for early diagnosis and prognosis of kidney diseases.
关键词
循环游离DNA/肾脏疾病/生物标志物/诊断及预后Key words
Circulating free DNA/Kidney disease/Biomarkers/Diagnosis and prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据