Analysis of prescription rules of myasthenia gravis based on implicit structure model combined with association rules
Objective To study the prescription rule of myasthenia gravis(MG)based on implicit structure model and association rule analysis,and to provide reference for clinical diagnosis and treatment.Methods The literatures related to the treatment of MG by traditional Chinese medicine in CNKI,Wanfang Data,VIP,and SinoMed from inception to February,2024 were searched respectively,and the qualified literature information was extracted and the database was established.The latent structure model and association rules of traditional Chinese medicine with frequency＞3.00％were analyzed by using Lantern 5.0 and Rstudio software respectively,and combined with frequency analysis,the drug use rules of MG were summa-rized.Results A total of 160 literatures were included,180 prescriptions,and 154 kinds of traditional Chinese medicine were screened out,and the total frequency of traditional Chinese medicine was 1 860 times.The traditional Chinese medicine with a frequency＞3.00％included Astragali Radix,Atracty-lodis Macrocephalae Rhizoma,Angelicae Sinensis Radix,Cimicifugae Rhizoma,Bupleuri Radix,etc.The categories of Chinese medicine mostly belong to tonifying deficiency drugs,relieving superficies drugs,and regulating qi drugs.A total of 10 latent variables,20 latent categories were obtained by latent structure analysis,which were classified into seven categories by combining with professional knowledge,including spleen and stomach weakness syndrome,spleen deficiency dampness stagnation syndrome,blood stasis syndrome,etc.There were 12 core prescriptions,including Buzhong Yiqi Decoction,Qiangji Jianli Yin,Xuefu Zhuyu Decoction,etc.A total of 27 strong association rules were obtained by association rule analy-sis,the highest support degree was Atractylodis Macrocephalae Rhizoma-Astragali Radix,the highest confidence degree was Cimicifugae Rhizoma-Cimicifugae Rhizoma.Conclusion The pathogenesis of MG is complex,and most of which are deficiency of the root and excess of the superficial.The affected organs are closely related to the spleen,lung,liver,and kid-ney.The treatment of MG is mainly based on tonifying the middle and replenishing qi,combined with the treatment of clearing heat and removing dampness,dispelling blood stasis and reducing turbidity according to clinical manifestations.
Myasthenia gravisLatent structureAssociation ruleMedication ruleTraditional Chinese medicine
NETL
NSTL
万方数据
