Neuronal damage and repair of intracerebral hemorrhage
Intracerebral hemorrhage is the second common subtype of stroke,which is mainly caused by hypertension.Its mortality and incidence rate are higher than those of ischemic stroke.Primary and secondary brain damage caused by intracerebral hemorrhage significantly damages structure and function of neurons,affects patients'neurological function and quality of life.The mechanisms of neuronal damage include immune inflammatory response,oxidative stress,and iron toxicity.In terms of neuronal protection and repair mechanisms,the dual role of immune cells(such as microglia)in neuroinflammation is mainly analyzed.Microglia can both clear damaged cells and cause neuronal damage;astrocytes provide protection for neurons by transferring mitochondria and absorbing glutamate.This article summarizes the potential of stem cell therapy,especially the application of neural stem cells and mesenchymal stem cells in promoting neuronal regeneration and tissue repair,and explores the importance of brain-derived neurotrophic factor in neuroprotection and recovery.Ferroptosis and oxidative stress are key factors leading to neuronal damage after intracerebral hemorrhage,and regulating these mechanisms is crucial for improving neuronal survival rates.Despite the increasing number of preclinical and clinical studies on intracerebral hemorrhage in recent years,effective treatment methods are still insufficient.Therefore,in-depth research on relevant molecular mechanisms and treatment strategies has become an important task in the future,especially in inflammation regulation,oxidative stress relief,and neuronal protection and regeneration.This article aims to clarify the research direction and provide a theoretical basis for improving the rehabilitation rate and quality of life of patients with intracerebral hemorrhage.
NeuronsIntracerebral hemorrhageNeuronal damageNeuronal repairMechanism research
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