Exploring the causal relationship between body mass index and hallux valgus based on two-sample Mendelian randomization
Objective To analyze the relationship between body mass index(BMI)and hallux valgus(HV)by Mendelian randomization(MR).Methods Using the aggregate data of published GWAS database as the data source,single nucleotide polymorphism(SNP)strongly correlated with BMI was selected as instrumental variables.As the outcome variable,HV was selected by weighted median method,MR-Egger regression method,inverse variance weighted(IVW)method,simple model,and weighted model were used to analyze the causal association between BMI and HV,and IVW method was used as the main analysis method.Meanwhile,Cochran's Q test was used to analyze heterogeneity.Multi-effect analysis was carried out by MR-Egger and sensitivity analysis by leave-one method to evaluate the reliability of the results.Results A total of 415 SNPs were selected as instrumental variables for MR Analysis.IVW method analysis results showed that BMI was positively correlated with HV(OR=1.167,95％CI:1.022-1.331,P=0.022).Heterogeneity analysis showed that there was heterogeneity among SNPs(IVW method:Q=586.270,P＜0.001;MR-Egger regression method:Q=585.45,P＜4.49 × 10-8),so the IVW method result was mainly concerned.The result of MR-Egger intercept method showed that P＞0.05,so there was no horizontal pleiotropy.The leave-one-out analysis showed robust results.Meanwhile,reverse MR analysis results did not support reverse causality.Conclusion There is a positive causal association between BMI and HV.
Hallux valgusBody mass indexMendelian randomizationCausal relationship
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