摘要
目的 研究生长于撒哈拉沙漠的药用植物含生草的化学成分.方法 含生草干燥全草经粉碎、脱脂后用丙酮渗漉提取,提取物通过硅胶、聚酰胺和葡聚糖凝胶(Sephadex)LH-20等柱层析进行分离纯化.测定所得化合物的理化性质,应用波谱学技术结合文献报道确定其化学结构.结果 从含生草丙酮提取物中初步分离得到了 7个黄酮类化合物、2个黄酮-木脂素和1个甾醇苷,分别鉴定为3'-O-甲基花旗松素(1)、阿那他汀A(2)、2,3-脱氢水飞蓟宾(3)、水飞蓟宾A(4)、香橙素(5)、(2R,3R)-4'-O-甲基花旗松素-3-O-β-D-葡萄糖苷(6)、异槲皮苷(7)、槲皮素(8)、芦丁(9)和胡萝卜苷(10).结论 从含生草中初步分离纯化得到10个化合物,其中化合物3、6和7为首次从本植物中分离得到.
Abstract
Objective To study on the chemical constituents from a medicinal plant Anastatica Hierochuntica L.which is an annual plant growing in the Sahara-Arabian deserts.Methods The dried whole herb containing Anastatica Hierochuntica L.was pulverized,defatted,and extracted by acetone percolation,and the extracts were segregated and depurated by column chromatography on silica gel,polyamide,and dextran gel(Sephadex)LH-20.The physicochemical properties of the resulting compounds were determined and spectroscopic techniques were applied to determine their chemical structures in conjunction with literature reports.Results Seven flavonoids,two flavone-lignans,and one sterol glycoside were isolated from acetone extract of A nastatica Hierochuntica L Preliminarily,which were identified as 3'-O-methy-ltaxifolin(1),anastatin A(2),2,3-dehydrosilybin(3),silybin A(4),aromadendrin(5),(2R,3R)-4'-O-methyltaxifolin-3-O-β-D-glucopyranoside(6),iso-quercitroside(7),quercetin(8),rutin(9),and daucosterol(10)in proper order.Conclusion Among the ten known compounds,3,6,and 7 are isolated from this plant for the first time.
基金项目
新疆维吾尔自治区自然科学基金面上项目(2018D01A36)
NETL
NSTL
万方数据