泡沫细胞演变过程及其与乳腺疾病相关研究进展
Research progress on evolution of foam cell and its relationship with breast diseases
殷玉莲 1陈红风1
作者信息
- 1. 上海中医药大学附属龙华医院中医乳腺科,上海 200032
- 折叠
摘要
泡沫细胞由吞噬脂质的巨噬细胞转化而来.泡沫细胞的形成涉及脂蛋白的过度吸收、胆固醇酯化增强和胆固醇清除受阻,而其降解则依赖于多种流出受体和胆固醇逆转运途径.泡沫细胞在心血管疾病中的作用被广泛研究,但其与乳腺疾病存在相关性.本文综述泡沫细胞的形成、降解过程和影响因素,并探讨其在乳腺疾病病理变化中的意义,为后续靶向调节其细胞代谢诊疗乳腺疾病提供新视角.
Abstract
Foam cell is derived from the transformation of macrophages that have ingested lipids.The formation of foam cell involves excessive absorption of lipoproteins,enhanced cholesterol esterification,and hindered cholesterol clearance,while its degradation depends on multiple efflux receptors and cholesterol reversal pathways.The role of foam cell in cardiovascular disease has been widely studied,but it is correlated with breast disease.This article reviews formation,degradation process and influencing factors of foam cells,and discusses their significance in pathological changes of breast diseases,and provides a new perspective for subsequent targeted regulation of cell metabolism in diagnosis and treatment of breast diseases.
关键词
泡沫细胞/形成/降解/乳腺疾病Key words
Foam cells/Formation/Degradation/Breast diseases引用本文复制引用
基金项目
国家自然科学基金资助项目(82104854)
上海中医药大学附属龙华医院促进市级医院临床技能与临床创新三年行动计划项目(SHDC2020CR2051B)
出版年
2024
NETL
NSTL
万方数据