Research progress on the role and mechanism of autophagy-NLRP3 inflammasome pathway in enteritis
The autophagy process regulated by autophagy-related genes plays a vital role in cell survival and maintenance of intracellular homeostasis by promoting degradation and recycling of damaged and aged substances in cells.As a major component of innate immunity,nucleotide-binding oligomeri zation domain-like receptors protein 3(NLRP3)inflammasome plays a role in the occurrence and development of various diseases in the body.The autophagy-NLRP3 inflammasome pathway is closely related to the occurrence and development of inflammatory bowel disease,radiation enteritis,infectious enteritis and ischemic enteritis.It mainly inhibits activation of NLRP3 inflammasome in intestinal tissue through various pathways such as degradation of NLRP3 inflammasome components and inhibition of reactive oxygen species production,thereby reducing intestinal related inflammatory reactions.This article reviews research progress on the role and mechanism of autophagy-NLRP3 inflammasome pathway in enteritis in the past five years,as well as typical NLRP3 inflammasome inhibitors discovered in current research,in order to provide new ideas for the development of new drugs related to enteritis.
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