摘要
功能性便秘是临床上常见的消化系统疾病,发病率逐年上升,对人们的身心健康和生活质量造成严重影响.其病因机制复杂,目前尚未明确.中医学认为便秘的病机基本概括为大肠传导失常,同时与脾胃、心、肺、肝、肾等多个脏腑密切相关.西医学认为功能性便秘的机制主要与脑-肠-菌轴、精神心理因素、肠神经系统、肠神经递质、水通道蛋白、Cajal间质细胞及结肠平滑肌等有关.本文从中西医两个方面对功能性便秘发病机制的相关研究进行总结,并提出对未来的展望,旨在为进一步研究提供新的思路和参考.
Abstract
Functional constipation is a common digestive system disease in clinic.The incidence rate is increasing year by year,which has a serious impact on people's physical and mental health and quality of life.The pathogenesis of this disease is complex and currently unclear.Traditional Chinese medicine believes that the pathogenesis of constipation is mainly due to conduction disorders in large intestine,which are closely related to multiple organs such as spleen,stomach,heart,lungs,liver and kidney.Western medicine believes that the mechanism of functional constipation is mainly related to brain-gut-microbiota axis,psychological factors,enteric nervous system,enteric neurotransmitters,aquaporins,Cajal-interstitial cells and colon smooth muscle.This article summarizes relevant research on the pathogenesis of functional constipation from two aspects of traditional Chinese and western medicine,and proposes prospects for the future,aiming to provide new ideas and references for further research.
基金项目
河南省中医药科学研究专项课题(20-21ZY2231)
河南省中医药拔尖人才培养项目专项课题(2022ZYBJ22)
NETL
NSTL
万方数据