Meta-analysis of effect of thiamine supplementation on prognosis in cri-tically ill patients
Objective To assess the effect of thiamine supplementation in critically ill patients based on a meta-analysis of randomized controlled trials(RCT)and propensity score matching(PSM)studies.Methods RCT and PSM studies on the effects of thiamine supplementation on critically ill patients published from inception to May 2024 in the CNKI,Wanfang Data,VIP,Scopus,PubMed,Cochrane,and Embase databases were searched.The control group was treated with basic treatment,and the experimental group was treated with thiamine supplement based on the control group.The main outcome measures were mortality,secondary outcome measures included intensive care unit stay and total length of stay.The two researchers conducted literature screening and data extraction independently,used the Cochran bias risk assessment tool to evaluate the methodological quality of the included RCT studies,and used the Newcastle-Ottawa score to evaluate the methodological quality of the included PSM studies.Meta-analysis was performed using RevMan 5.3 software,and funnel plot was used to assess publication bias in the included literature.Results A total of 10 studies(six RCT and four PSM)were ultimately included,with 5 758 patients.Through the results of meta-analysis,it was found that mortality rate of experimental group was lower than that of control group(RR=0.79,95％CI:0.69 to 0.89,P=0.000 2).In terms of secondary outcomes,the length of intensive care unit stay(MD=1.25,95％CI:-0.49 to 2.99,P=0.16)and the total length of hospital stay(MD=0.77,95％CI:-0.51 to 2.04,P=0.24)were not significantly different between the experimental group and the control group.Conclusion In critically ill patients,thiamine supplementation is not associated with length of hospital stay,but reduced mortality and improved prognosis.
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