Discussion on the medication rules of traditional Chinese medicine in treating primary insomnia based on data mining
Objective To analyze the syndromes of primary insomnia and traditional Chinese medicine prescriptions in literature and periodicals based on data mining technology,and to explore the medication rules of primary insomnia.Methods The literatures and periodicals of CNKI,VIP,and Wanfang Data were searched online by computer,and the search time was set to be from January 2013 to December 2023.The qualified literatures and periodicals were selected according to inclusion and exclusion criteria,and then the data were input and normalized by Excel 2023.The Python script was used for statistical analysis of the entered prescriptions,syndrome types,and drugs,and the frequency of each syndrome type,drug,and prescription was obtained.Secondly,Excel 2023 software was used to record and count the four nature,five flavours,channel tropism,and efficacy use frequency of the above-mentioned drugs,so as to establish a primary insomnia database based on literature journals.Statistical software Excel 2023,SPSS Statistics 27.0,IBM SPSS Modeler 18.0 were used to analyze the frequency,association rules,and cluster analysis of traditional Chinese medicine syndrome types,drugs,four nature and five flavours,channel tropism,and prescription.Results In this study,a total of 90 prescriptions for treating primary insomnia involving 108 kinds of traditional Chinese medicine were collected,and the core syndrome was type of deficiency of both heart and spleen.The top ten frequently used were Glycyrrhizae Radix Et Rhizoma,Ziziphi Spinosae Semen,Poria,Angelicae Sinensis Radix,Atractylodis Macrocephalae Rhizoma,Coptidis Rhizoma,Polygalae Radix,Bupleuri Radix,Codonopsis Radix,Pinelliae Rhizoma.The natures and flavours were mainly cold,warm,sweet,bitter,and pungent.The drugs were mostly liver,heart,and kidney channels.The main drugs were tonifying deficiency drugs,and the prescription was Guipi Decoction.Association rule analysis showed that there were strong links among Poria,Glycyrrhizae Radix Et Rhizoma,Ziziphi Spinosae Semen,Atractylodis Macrocephalae Rhizoma,and Angelicae Sinensis Radix,and five drug formulations were obtained by cluster analysis.The association rule analysis of type of deficiency of both heart and spleen showed the strongest correlation among Glycyrrhizae Radix Et Rhizoma,Angelicae Sinensis Radix,Atractylodis Macrocephalae Rhizoma,and Ziziphi Spinosae Semen.Conclusion The primary insomnia is mainly caused by the deficiency of both heart and spleen.The treatment of deficiency medicine,invigorating qi and invigorating spleen,nourishing blood and calming the spirit,Guipi Decoction is the core prescription of treatment.
Data miningPrimary insomniaTraditional Chinese medicineMedication rules
NETL
NSTL
万方数据
