目的 探讨临床中药联合溶栓治疗急性脑梗死的用药规律.方法 检索中国知网、万方数据知识服务平台、维普网、PubMed、Web of Science核心合集数据库,筛选文献,建立中药处方数据库,进行药物频次、四气、五味、归经、功效类别统计.运用SPSS Modeler 18.0软件进行中药间关联规则分析,并运用Gephi 0.10.1软件进行复杂网络分析,包括k-core层次分析和社团分析,探究核心药物组合.结果 共纳入46个中药处方,涉及116味中药,频次前5位的中药为川芎、黄芪、当归、红花、桃仁.药类频次前5位的中药类别依次是活血化瘀药、补虚药、平肝息风药、清热药、化痰止咳平喘药.药性多为平、寒、凉,药味以苦、甘、辛为主,主要归肝、脾、心经.关联分析及网状图显示,川芎-桃仁-当归、桃仁-红花-当归、川芎-丹参-黄芪为常用中药组合;复杂网络k-core层次分析显示,"当归、川芎、红花、黄芪、丹参、桃仁、大黄、天麻、天南星、甘草、赤芍、石菖蒲、半夏、地龙、水蛭、全蝎"是核心中药处方;社团分析得到3个核心中药群.结论 中药联合溶栓治疗急性脑梗死强调以"补气活血"为主要治疗原则,同时注重平肝息风、健脾化痰,适当应用虫类药是临床治疗新思路.
Analysis of medication rules in traditional Chinese medicine combined with thrombolytic therapy in the treatment of acute cerebral infarction based on data mining
Objective To explore the medication rule of clinical traditional Chinese medicine combined with thrombolytic therapy in the treatment of acute cerebral infarction.Methods The CNKI,Wanfang Data,VIP,PubMed,and Web of Science Core Collection Database were searched,literature was screened,and a traditional Chinese medicine prescription database was established,and the statistics of drug frequency,four natures,five flavours,channel tropism,and efficacy were carried out.SPSS Modeler 18.0 software was used to analyze association rules among traditional Chinese medicines,and Gephi 0.10.1 software was used to conduct complex network analysis,including k-core hierarchical analysis and community anal-ysis,the core drug combinations were explored.Results A total of 46 traditional Chinese medicine prescriptions were in-cluded,involving 116 kinds of traditional Chinese medicines.The top five most frequently used traditional Chinese medicines were Chuanxiong Rhizoma,Astragali Radix,Angelicae Sinensis Radix,Carthami Flos,and Persicae Semen.The top five categories of traditional Chinese medicine in terms of drug frequency were promoting blood circulation for re-moving blood stasis drugs,tonifying deficiency drugs,suppressing hyperactive liver for calming endogenous wind drugs,heat clearing drugs,and phlegm resolving,cough relieving,and asthma relieving drugs.The drug natures were mostly mild,cold,and cool,and the drug flavours were mainly bitter,sweet,and pungent,mainly returning to the liver,spleen,and heart channels.Correlation analysis and network diagram showed that Chuanx-iong Rhizoma-Persicae Semen-Angelicae Sinensis Radix,Persicae Semen-Carthami Flos-Angelicae Sinensis Radix,Chuanxiong Rhizoma-Salviae Miltiorrhizae Radix Et Rhi-zoma-Astragali Radix were commonly used traditional Chinese medicine combinations.Complex network k-core hierarchi-cal analysis showed that"Angelicae Sinensis Radix,Chuanxiong Rhizoma,Carthami Flos,Astragali Radix,Salviae Milti-orrhizae Radix Et Rhizoma,Persicae Semen,Rhei Radix Et Rhizoma,Gastrodiae Rhizoma,Arisaematis Rhizoma,Gly-cyrrhizae Radix Et Rhizoma,Paeoniae Radix Rubra,Acori Tatarinowii Rhizoma,Pinelliae Rhizoma,Pheretima,Hirudo,Scorpio"were the core traditional Chinese medicine prescriptions.Three core traditional Chinese medicine groups were ob-tained by community analysis.Conclusion Traditional Chinese medicine combined with thrombolytic therapy in the treat-ment of acute cerebral infarction emphasizes"invigorating qi and activating blood"as the main therapeutic principle,and pays attention to suppressing hyperactive liver for calming endogenous wind,strengthening spleen and eliminating phlegm.Appropriate application of insecticides is a new idea of clinical treatment.
StrokeCerebral infarctionTraditional Chinese medicineThrombolysisData miningMedication rules
NETL
NSTL
万方数据
