摘要
目的 探讨老年健康体检人群残余胆固醇(RC)与动脉硬化(AS)的相关性.方法 回顾性分析皖南医学院第一附属医院2023年6月至10月进行健康体检的1 013名老年人,依据臂踝动脉脉搏波传导速度(baPWV)测量动脉损伤程度.根据baPWV测量结果将体检人群分为AS组(baPWV≥1 400 cm/s)与非AS组(baPWV＜1400 cm/s).采用Spearman秩相关分析探讨RC与AC发病的其他危险因素的相关性,采用二元logistic回归分析(向前法)探讨RC是否为老年健康体检人群AS发病的影响因素.结果 Spearman秩相关分析显示,RC与高血压、空腹血糖、甘油三酯、球蛋白、谷丙转氨酶、天冬氨酸转氨酶/谷丙转氨酶呈正相关(rs=0.080、0.070、0.475、0.196、0.122、0.085,P＜0.05);与高密度脂蛋白胆固醇(HDL-C)、白蛋白/球蛋白呈负相关(rs=-0.093、-0.170,P＜0.05).二元 logistic回归分析显示,高 RC 水平(OR=1.453,95％CI=1.024～2.061)、高血压(OR=2.071,95％CI=1.493～2.872)、白细胞计数(OR=1.106,95％CI=1.012～1.208)、脉压差(OR=1.018,95％CI=1.007～1.028)、天冬氨酸转氨酶/谷丙转氨酶(OR=1.771,95％CI=1.303～2.406)是老年健康体检人群发生AS的独立危险因素,高密度脂蛋白胆固醇(OR=0.386,95％CI:0.255～0.583)是老年健康体检人群AS的保护因素.结论 老年健康体检人群发生AS与高RC水平有关,可通过监测RC水平降低其AS发生率.
Abstract
Objective To explore the correlation between residual cholesterol(RC)and arteriosclerosis(AS)in elderly healthy physical examination population.Methods A retrospective analysis was performed on 1 013 elderly people who un-derwent physical examination in the First Affiliated Hospital of Wannan Medical College from June to October 2023,and the degree of arterial injury was measured according to arm and ankle artery pulse wave conduction velocity(baPWV).Accord-ing to the baPWV measurement results,the physical examination population was divided into AS group(baPWV ≥ 1 400 cm/s)and non-AS group(baPWV＜1 400 cm/s).The Spearman rank correlation analysis was used to explore the association of RC and other risk factors for AS onset,and the binary logistic regression analysis(forward method)was used to explore the influencing factors of the incidence of AS in the elderly health examination population.Results Spearman Rank correlation analysis showed that RC was positively associated with hypertension,fasting Plasma Glucose,triglyceride,globulin,aspartate aminotransferase,aspartate aminotransferase/alanine transami-nase(rs=0.080,0.070,0.475,0.196,0.122,0.085,P＜0.05);and negatively associated with high density lipoprotein choles-terol,albumin/globulin(rs=-0.093,-0.170,P＜0.05).Binary logistic regression analysis showed that high RC level(OR=1.453,95％CI=1.024-2.061),hypertension(OR=2.071,95％CI=1.493-2.872),white blood cell count(OR=1.106,95％CI=1.012-1.208),pulse pressure difference(OR=1.018,95％CI=1.007-1.028),aspartate aminotransferase/alanine aminotransferase(OR=1.771,95％CI=1.303-2.406)were independent risk factors for AS in the elderly healthy population.High density lipoprotein cholesterol(OR=0.386,95％CI:0.255-0.583)was a protective factor for AS in the elderly healthy population.Conclusion The occurrence of AS in elderly healthy physical examination population is related to high RC level,and the incidence of AS can be reduced by monitoring RC level.
基金项目
安徽省社会科学创新发展研究课题(2023CX102)
安徽省芜湖市科技计划项目(2023rkx15)
NETL
NSTL
万方数据