Expression and clinical significance of integrin αM in peripheral blood mononuclear cells of pregnant women with preeclampsia
Objective To investigate the expression level of integrin αM(ITGAM)on peripheral mononuclear cells of pregnant women with preeclampsia and its potential clinical significance.Methods A total of 40 pregnant women with preeclampsia who were treated in the Second Hospital & Clinical Medical School,Lanzhou University from March 2023 to March 2024 were selected as the case group,and they were divided into two groups according to the severity of the disease:mild preeclampsia group(M-PE,19 cases)and severe preeclampsia group(S-PE,21 cases).Another 40 healthy pregnant women with matching age and gestational age who were admitted to the Second Hospital & Clinical Medical School Lanzhou University during the same period were selected as the control group.Flow cytometry was used to detect ITGAM expression on peripheral blood mononuclear cells of pregnant women in two groups,and the correlation between ITGAM expression and clinical features of pregnant women in each group was analyzed.Results The expression level of ITGAM on peripheral blood mononuclear cells of the case group was lower than that of the control group(P＜0.05),and further analysis showed that the expression level of ITGAM in the S-PE group was lower than that in the control group(P＜0.05),there was no statistical significance between control and M-PE group,and between S-PE and M-PE group.The expression level of ITGAM on the surface of monocytes in the case group was negatively correlated with 24 h urinary protein quantity and LDH(r=-0.344,-0.384,P=0.030,0.014),and positively correlated with ALB(r=0.389,P=0.013).The expression of ITGAM in the control group was negatively correlated with platelet(r=-0.383,P=0.015).Conclusion The decreased expression level of ITGAM on peripheral blood mononuclear cells of preeclampsia pregnant women may be involved in its pathogenesis,and may be related to the degree of kidney injury and the severity of the disease.
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