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羧甲基壳聚糖的取代度及保湿性

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以不同分子量的壳聚糖为原料制备了一系列羧甲基壳聚糖，测定了取代度（DS）和分子量(Mη)，并用FT-IR及13CNMR进行了分子结构表征.结果表明,在2位氨基及3、6位羟基上均发生了羧甲基化反应，产物为N,O-羧甲基壳聚糖(NOCC).取代度大小顺序为:OH-6＞OH-3＞—NH2,且总取代度随壳聚糖分子量的降低明显增大.N,O-羧甲基壳聚糖具有与透明质酸相似的吸湿、保湿效果，其吸湿性能随分子量的增大而增强，保湿性能随取代度的增高而增强，分子量介于0.56×104～8.6×104，取代度大于1.0的产品，其保湿性能优于透明质酸.
Study on the Substitution and Moisture-Retention Capacity of Carboxymethyl Chitosan
A series of N,O-carboxymethylchitosan(CM-chitosan) were prepared.The position and degree of substitution were determined by potentiometric titration, IR and 13C NMR. The results indicated that the degree of substitution of the compounds increased significantly with decrease of molecular weight of chitosan and the carboxymethylation reactivity decreased in the order OH-6＞OH-3＞NH2. The moisture-absorption and moisture-retention properties of CM-chitosans and moisture-retention properties of CM-chitosans were found quite similar to those of hyaluronic acid. The moisture absorbability increased with increasing in molecular weight and moisture retention capacity of CM-chitosas with the degree of substitution. The CM-chitosans with molecular weight from 0.56×104 to 8.6×104 and degree of substitution greater than 1.0 had better moisture-absorption moisture-retention capacity than hyaluronic acid.

陈凌云、杜予民、肖玲、覃彩芹

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武汉大学化学与环境科学学院

羧甲基壳聚糖 吸湿性 保湿性 取代度 分子量

国家自然科学基金中金集团资助项目

29977014

2001

应用化学
中国化学会 中国科学院长春应用化学研究所

应用化学

CSCD北大核心
影响因子：0.559
ISSN：1000-0518
年,卷(期)：2001.18(1)
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