Research Progress in Design,Synthesis and Properties of Organic Octupolar Two-Photon Excited Fluorescence Materials
Two-photon fluorescence has the advantages of large penetration depth and high spatial resolution,and has an important application prospect in the field of biological imaging.With the continuous innovation and development of related research,organic dipole and quadrupole molecules cannot exhibit the desired two-photon excited fluorescence properties due to the limitations of their own structure and properties,and cannot be designed and regulated in their structure properties.So it is increasingly unable to meet the needs of practical applications.Compared with organic dipole and quadrupole molecules,organic octupolar molecules have obvious advantages in this aspect.Through the diversified structural"clipping"on the multiple structural units(central core,branches and π-conjugate bridges),the coupling between different branches can be greatly improved and the two-photon absorption cross section can be also improved.At the same time,the water solubility,membrane permeability,biocompatibility and laser stability of the molecule can be further optimized.Therefore,in recent years,more and more research has focused on organic octupole two-photon excited fluorescence materials.The research progress in design,synthesis and properties of organic octupolar two-photon excited fluorescence materials in recent five years is reviewed.The discussion focuses on the design and synthesis of novel central core structure,the improvement of two-photon absorption response of organic blue two-photon excited fluorescence materials,the improvement of photostability and water solubility of two-photon excited fluorescence materials,and the expansion of excitation wavelength from near infrared region 1 to near infrared region 2.The further development trend of this field is also discussed,which provides a basis for the further development and application of organic octupolar two-photon excited fluorescence materials.
Two-photon excited fluorescenceOrganic octupolar moleculeDesign and synthesisStructure and performanceBioimaging
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